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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/4453


    標題: Sulfinpyrazone 控釋劑型:體內體外相關之研究
    Controlled-Release Formulations of Sulfinpyrazone:In Vitro and In Vivo Studies
    作者: 張麗珍
    Chen-Chang Li
    貢獻者: 宋國峻
    嘉南藥理科技大學:生物科技研究所
    關鍵字: 控釋劑型
    Sulfinpyrazone
    Controlled-Release Formulations
    日期: 2003
    上傳時間: 2008-10-08 15:45:40 (UTC+8)
    摘要: Matrix system機轉製造控釋劑型藥物已廣泛被藥學界研究。以往之研究都著重在藥物劑型配方對於體外溶離之影響,然而劑型配方對於藥物在體內之表現影響則研究不多。所以本研究乃以Sulfinpyrazone為一模式藥物,以了解其由matrix錠劑中不同基質之體外溶離及體內吸收之狀況。本研究中之錠劑以濕粒法製成,錠劑中分別含有Hydroxypropylmethylcellulose (HPMC)或Glyceryl behenate (C-888)。而實驗之結果,HPMC及C-888含量較低的劑型具有較快之溶離速率,且不同基質的劑型其溶離曲線是不相同的,此結果證明體外的溶離的確會被劑型配方中的HPMC及C-888所影響。在以狗為模式動物之體內藥動試驗方面,將以含C-888為基質之Sulfinpyrazone控釋劑型與原廠(速放)製劑以動物試驗結果做比較,發現此控釋製劑具有較低之Cmax,較長之Tmax及相仿之AUC,顯示本製劑確有控釋效果,其緩釋效果並和體外緩釋溶離結果是一致的。
    The major purpose of this study was to evaluate the effects of formulation variables on drug release from hydroxypropylmethylcellulose (HPMC) and glyceryl behenate(C-888) based matrix tablets. Sulfinpyrazone was used as model drug and beagle dog was used as the model animal. For the HPMC
    based matrix tablets, drug release was found to be a function of HPMC concentration, with slower drug release for tablet containing higher amount of HPMC. Similar results were also observed for the C-888 based matrix tablets, i.e., drug release was also slower for tablet containing more C-888.
    The animal results indicate that the in vitro and in vivo performance of model drug was correlated and the model drug can be sustained well by the C-888 based formulations.
    關聯: 校內校外均不公開
    Appears in Collections:[生物科技系(所)] 博碩士論文

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