資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://ir.cnu.edu.tw/handle/310902800/34933
|
| 標題: | Association of Dip in eGFR With Clinical Outcomes in Unilateral Primary Aldosteronism Patients After Adrenalectomy |
| 作者: | Chen, Jui-Yi
Huang, Kuo-How
Lin, Yen-Hung
Chueh, Jeff S.
Wang, Hsien-Yi
Wu, Vin-Cent |
| 貢獻者: | Chi Mei Med Ctr, Dept Internal Med, Div Nephrol
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Natl Taiwan Univ, Coll Med, Dept Urol
Natl Taiwan Univ Hosp, Dept Urol
Natl Taiwan Univ Hosp, Dept Internal Med
Chia Nan Univ Pharm & Sci, Coll Leisure & Recreat Management, Dept Sport Management
Natl Taiwan Univ Hosp
Natl Taiwan Univ Hosp, Primary Aldosteronism Ctr |
| 關鍵字: | primary aldosteronism
adrenalectomy
eGFR dip
major adverse kidney event |
| 日期: | 2024 |
| 上傳時間: | 2024-12-25 11:05:51 (UTC+8) |
| 出版者: | ENDOCRINE SOC |
| 摘要: | Context: Primary aldosteronism (PA) leads to kidney function deterioration after treatment, but the effects of the estimated glomerular filtration rate (eGFR) dip following adrenalectomy and its long-term implications are unclear.Objective: This study aims to examine eGFR dip in patients with unilateral PA (uPA) after adrenalectomy and clarify their long-term prognosis.Methods: This multicenter prospective population-based cohort study, enrolled patients with uPA who underwent adrenalectomy. Patients were divided into 4 groups based on their eGFR dip ratio. Outcomes investigated included mortality, cardiovascular composite events, and major adverse kidney events (MAKEs).Results Among 445 enrolled patients, those with an eGFR dip ratio worse than -30% (n = 74, 16.6%) were older, had higher blood pressure, higher aldosterone concentration, and lower serum potassium levels. During 5.0 +/- 3.6 years of follow-up, 2.9% died, 14.6% had cardiovascular composite events, and 17.3% had MAKEs. The group with eGFR dip worse than -30% had a higher risk of MAKEs (P < .001), but no significant differences in mortality (P = .295) or new-onset cardiovascular composite outcomes (P = .373) were found. Multivariate analysis revealed that patients with an eGFR dip ratio worse than -30% were significantly associated with older age (odds ratio [OR], 1.04), preoperative eGFR (OR, 1.02), hypokalemia (OR, 0.45), preoperative systolic blood pressure (OR, 1.03), and plasma aldosterone concentration (OR, 0.99).Conclusion: Within 5 years post adrenalectomy, 17.3% of patients had reduced kidney function. Notably, individuals with an eGFR dip ratio worse than -30% faced higher MAKE risks, underscoring the need to monitor kidney function in PA patients after surgery. |
| 關聯: | Journal of Clinical Endocrinology & Metabolism, v.109, n.3 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
[運動管理系] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| dgad709.pdf | | 466Kb | Adobe PDF | 2 | 檢視/開啟 | | index.html | | 0Kb | HTML | 3 | 檢視/開啟 |
|
在CNU IR中所有的資料項目都受到原著作權保護.
|
