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| 標題: | Association of vitamin D deficiency with post-stroke depression: a retrospective cohort study from the TriNetX US collaborative networks |
| 作者: | Ho, Chun-Ning
Sun, Cheuk-Kwan
Wu, Jheng-Yan
Chen, Jen-Yin
Chang, Ying-Jen
Chen, I-Wen
Hung, Kuo-Chuan |
| 貢獻者: | Chi Mei Med Ctr, Dept Anesthesiol
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm, Coll Recreat & Hlth Management
Southern Taiwan Univ Sci & Technol, Dept Biotechnol & Food Technol
I Shou Univ, Eda Dachang Hosp, Dept Emergency Med
I Shou Univ, Coll Med, Sch Med Int Students
Chi Mei Med Ctr, Dept Nutr
Natl Sun Yat sen Univ, Coll Med, Sch Med
Chi Mei Med Ctr, Dept Anesthesiol |
| 關鍵字: | post-stroke depression
vitamin D deficiency
propensity score matching
stroke
vitamin D |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:04:58 (UTC+8) |
| 出版者: | FRONTIERS MEDIA SA |
| 摘要: | BackgroundPost-stroke depression (PSD) affects up to one-third of patients who survive stroke. This matched cohort study aimed to investigate the relationship between vitamin D deficiency (VDD) and PSD using a global health research network. MethodsAdult patients with first-ever stroke were eligible for inclusion if their circulating vitamin D levels were available within 3 months before the onset of stroke. Patients were subdivided into those with VDD [VDD group, 25(OH) D < 20 ng/mL] and those with normal vitamin D levels [control group, 25(OH) D: 30-80 ng/mL]. By using propensity score matching (PSM), potential confounding factors were adjusted. The primary outcomes were the association of VDD with the risk of PSD at the 3-month and 12-month follow-ups, while the secondary outcomes were the relationships between VDD and the risk of pneumonia as well as emergency department visits at the 12-month follow-up. ResultsAfter PSM, 758 individuals were included in each group, with no significant differences in baseline characteristics. Musculoskeletal diseases, metabolic disorders, and hypertension were the three leading comorbidities in both the groups. The incidence of PSD was not significantly different between the two groups at the 3-month (5.8% vs. 4.7%, p = 0.358) and 12-month (11.6% vs. 10.2%, p = 0.364) follow-up. VDD was not associated with an increased risk of PSD at the 3-month [hazard ratio (HR) = 1.258, p = 0.358] or 12-month follow-up (HR = 1.210, p = 0.364). In addition, VDD was not associated with an increased risk of pneumonia (HR = 1.053, p = 0.823) or emergency visits at the 12-month follow-up (HR = 1.206, p = 0.148). ConclusionThe results revealed no significant link between VDD and PSD risk during the 3-month and 12-month follow-up periods, suggesting that VDD might not play a substantial role in PSD risk. However, further extensive studies employing a prospective design are necessary to explore the potential protective effects of vitamin D against PSD and validate these findings. |
| 關聯: | Frontiers in Nutrition, v.10, Article 1236233 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
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