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| 標題: | Efficacy of high-flow nasal oxygenation against peri- and post-procedural hypoxemia in patients with obesity: a meta-analysis of randomized controlled trials |
| 作者: | Hung, Kuo-Chuan
Ko, Ching-Chung
Chang, Po-Chih
Wang, Kuei-Fen
Teng, I-Chia
Lin, Chien-Hung
Huang, Ping-Wen
Sun, Cheuk-Kwan |
| 貢獻者: | Chi Mei Hospital
Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy & Science
Department of Health and Nutrition, Chia Nan University of Pharmacy & Science
Kaohsiung Medical University
Kaohsiung Medical University Hospital
Show Chwan Memorial Hospital
E-Da Hospital
I Shou University |
| 關鍵字: | preoxygenation
atelectasis
intubation
cannula
anesthesia
management
therapy |
| 日期: | 2022 |
| 上傳時間: | 2023-12-11 14:05:39 (UTC+8) |
| 出版者: | NATURE PORTFOLIO |
| 摘要: | This meta-analysis aimed at investigating the efficacy of high-flow nasal oxygenation (HFNO) against hypoxemia in patients with obesity compared with conventional oxygenation therapy and non-invasive ventilation. Databases were searched from inception to August 2021. Studies involving peri- or post-procedural use of HFNO were included. The primary outcome was risk of hypoxemia, while the secondary outcomes included status of oxygenation and carbon dioxide elimination. Ten randomized controlled trials (RCTs) were included. We found that HFNO prolonged the safe apnea time at induction compared to control group [mean difference (MD) = 73.88 s, p = 0.0004; 2 RCTs] with no difference in risk of peri-procedural hypoxemia [relative risk (RR) = 0.91, p = 0.64; 4 RCTs], minimum SpO2 (MD = 0.09%, p = 0.95; 4 RCTs), PaO2 (MD = - 8.13 mmHg, p = 0.86; 3 RCTs), PaCO2 (MD = - 6.71%, p = 0.2; 2 RCTs), EtCO2 (MD = - 0.28 mmHg, p = 0.8; 4 RCTs) between the two groups. HFNO also did not improve postprocedural PaO2/FiO2 ratio (MD = 41.76, p = 0.58; 2 RCTs) and PaCO2 (MD = - 2.68 mmHg, p = 0.07; 2 RCTs). This meta-analysis demonstrated that the use of HFNO may be associated with a longer safe apnea time without beneficial impact on the risk of hypoxemia, oxygenation, and CO2 elimination in patients with obesity. The limited number of trials warranted further large-scale studies to support our findings. |
| 關聯: | Scientific Reports, v.12, n.1, Article 6448 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
[保健營養系(所) ] 期刊論文
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