資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://ir.cnu.edu.tw/handle/310902800/34677
|
| 標題: | Overexpression of Dehydrogenase/Reductase 9 Predicts Poor Response to Concurrent Chemoradiotherapy and Poor Prognosis in Rectal Cancer Patients |
| 作者: | Chen, Tzu-Ju
Hsu, Bei-Hao
Lee, Sung-Wei
Yang, Ching-Chieh
Tian, Yu-Feng
Kuo, Yu-Hsuan
Li, Wan-Shan
Tsai, Hsin-Hwa
Wu, Li-Ching
Yeh, Cheng-Fa
Chou, Chia-Lin
Lai, Hong-Yue |
| 貢獻者: | Chi Mei Hospital
Chung Hua University
Chung Shan Medical University
Chung Shan Medical University Hospital
Chi Mei Hospital
Chi Mei Hospital
Chia Nan University of Pharmacy & Science
Chi Mei Hospital
Chi Mei Hospital
Chia Nan University of Pharmacy & Science
Chi Mei Hospital
National Sun Yat Sen University
Chi Mei Hospital
Chi Mei Hospital
China Medical University Taiwan
China Medical University Hospital - Taiwan
Chi Mei Hospital
Chia Nan University of Pharmacy & Science
China Medical University Taiwan |
| 關鍵字: | keratan sulfate
expression
glycosaminoglycan
differentiation
muc2 |
| 日期: | 2022 |
| 上傳時間: | 2023-12-11 14:04:41 (UTC+8) |
| 出版者: | FRONTIERS MEDIA SA |
| 摘要: | Objective: To reduce the risk of locoregional recurrence, the addition of neoadjuvant concurrent chemoradiotherapy (CCRT) is recommended before surgical management for rectal cancer patients. However, despite identical tumor histology, individual patient response to neoadjuvant CCRT varies greatly. Accordingly, a comprehensive molecular characterization that is used to predict CCRT efficacy is instantly needed.Methods: Pearson's chi-squared test was utilized to correlate dehydrogenase/reductase 9 (DHRS9) expression with clinicopathological features. Survival curves were created applying the Kaplan-Meier method, and the log-rank test was conducted to compare prognostic utility between high and low DHRS9 expression groups. Multivariate Cox proportional hazards regression analysis was applied to identify independent prognostic biomarkers based on variables with prognostic utility at the univariate level.Results: Utilizing a public transcriptome dataset, we identified that the DHRS9 gene is the most considerably upregulated gene related to epithelial cell differentiation (GO: 0030855) among rectal cancer patients with CCRT resistance. Employing immunohistochemical staining, we also demonstrated that high DHRS9 immunoexpression is considerably associated with an aggressive clinical course and CCRT resistance in our rectal cancer cohort. Among all variables with prognostic utility at the univariate level, only high DHRS9 immunoexpression was independently unfavorably prognostic of all three endpoints (all p <= 0.048) in the multivariate analysis. In addition, applying bioinformatic analysis, we also linked DHRS9 with unrevealed functions, such as keratan sulfate and mucin synthesis which may be implicated in CCRT resistance.Conclusion: Altogether, DHRS9 expression may serve as a helpful predictive and prognostic biomarker and assist decision-making for rectal cancer patients who underwent neoadjuvant CCRT. |
| 關聯: | PATHOLOGY & ONCOLOGY RESEARCH, v.28, n.CB2, pp.CC2, pp.-, |
| 顯示於類別: | [行政單位] 123
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| index.html | | 0Kb | HTML | 96 | 檢視/開啟 |
|
在CNU IR中所有的資料項目都受到原著作權保護.
|
