Upregulation of Cartilage Oligomeric Matrix Protein Predicts Poor Prognosis in Urothelial Carcinoma

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Title:	Upregulation of Cartilage Oligomeric Matrix Protein Predicts Poor Prognosis in Urothelial Carcinoma
Authors:	Kuo, Yu-Hsuan Lai, Hong-Yue Chan, Ti-Chun Hsing, Chung-Hsi Huang, Steven K. Hsieh, Kun-Lin Chen, Tzu-Ju Li, Wan-Shan Lu, Jhih-Cheng Li, Chien-Feng
Contributors:	Chi Mei Hospital Chia Nan University of Pharmacy & Science Chi Mei Hospital National Health Research Institutes - Taiwan Chi Mei Hospital Chi Mei Hospital Chang Jung Christian University Chi Mei Hospital Chung Hua University Chi Mei Hospital Chi Mei Hospital
Keywords:	bladder-cancer comp progression biomarker survival risk
Date:	2022
Issue Date:	2023-12-11 14:04:18 (UTC+8)
Publisher:	DOVE MEDICAL PRESS LTD
Abstract:	Purpose: Cartilage oligomeric matrix protein (COMP) is known as a large pentameric glycoprotein, which interacts with various extracellular matrix proteins in tissues. COMP has been reported to play a role in multiple connective tissue disorders. Recently, elevated COMP levels have been found to be associated with increased tumor size, metastases, faster recurrence of cancer, and overall poorer survival in several cancers. However, the clinical importance of COMP in urothelial carcinoma remains unclear. We investigated the association between COMP expression and clinical outcomes in urothelial carcinoma. Patients and Methods: In this retrospective study, we collected urothelial carcinoma (UC) tissue from 340 upper urinary tract UC (UTUC) patients and 295 urinary bladder UC (UBUC) patients. Pearson???s chi-square test, Kaplan???Meier analysis, and the multivariate Cox proportional hazards model was used to examine the relationship between COMP expression and patient characteristics, pathological findings, and patient survival, such as metastasis-free survival (MFS) and disease-specific survival (DSS). Results: A total of 295 UBUC patients and 340 UTUC patients were recruited. The COMP mRNA level was significantly higher among invasive tumors (pT2???pT4) than in noninvasive tumors (pTa-T1) in UBUC groups (P < 0.01). COMP overexpression was associated with advanced T stage, nodal metastases, vascular invasion, perineural invasion, high histological grade, and high mitotic rate in both UBUC and UTUC cohorts. COMP overexpression was predictive of shorter DSS (hazard ratio [HR] in UBUC, 3.986, P < 0.001; in UTUC, 2.283, P = 0.027] and MFS (HR in UBUC, 6.813, P < 0.001; in UTUC, 4.070, P < 0.001). Kaplan???Meier analysis demonstrated high COMP expression associated with poor DSS and MFS in UTUC and UBUC groups (all P < 0.0001). Conclusion: COMP overexpression was linked to poor clinical prognosis and poor pathological features in UC. These results suggest COMP as a biomarker for UC.
Relation:	ONCOTARGETS AND THERAPY, v.15, n.CB2, pp.CC2, pp.-,
Appears in Collections:	[Offices] 123

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