Associations between Sjogren Syndrome, Sociodemographic Factors, Comorbid Conditions, and Scleritis in a Taiwanese Population-Based Study

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Title:	Associations between Sjogren Syndrome, Sociodemographic Factors, Comorbid Conditions, and Scleritis in a Taiwanese Population-Based Study
Authors:	Jan, Ren-Long Ho, Chung-Han Wang, Jhi-Joung Tseng, Sung-Huei Chang, Yuh-Shin
Contributors:	Chi Mei Hospital Chang Jung Christian University Chi Mei Hospital Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy & Science Chi Mei Hospital National Cheng Kung University National Cheng Kung University Hospital Chi Mei Hospital
Keywords:	manifestations
Date:	2022
Issue Date:	2023-12-11 14:01:50 (UTC+8)
Publisher:	MDPI
Abstract:	This nationwide, population-based, retrospective, matched case-control study included 111,960 newly diagnosed patients with scleritis who were identified by the International Classification of Diseases, Ninth Revision, Clinical Modification code 379.0, selected from the Taiwan National Health Insurance Research Database. Demographic characteristics, Sjogren syndrome, and comorbid conditions within 1 year before the scleritis diagnosis were examined using univariate logistic regression analyses, and a paired t-test was used for continuous variables. Adjusted logistic regression was used to compare the prognosis odds ratio (OR) of the patients with scleritis with the controls. After adjustment for confounders, patients with Sjogren syndrome were remarkably more likely to have scleritis than the controls (OR = 33.53, 95% confidence interval (CI) = 27.43-40.97, p < 0.001). Other conditions found to have increased odds of scleritis included post ocular pterygium, glaucoma, and scleral surgery (OR = 4.01, 95% CI = 3.64-4.43; OR = 3.16, 95% CI = 2.24-4.47; OR = 6.83, 95% CI = 5.34-8.74, respectively); systemic infections, such as syphilis, tuberculosis, and a human herpes viral infection (OR = 4.01, 95% CI = 2.93-5.50; OR = 2.24, 95% CI = 1.94-2.58; OR = 8.54, 95% CI = 8.07-9.03, respectively); and systemic diseases, such as rheumatoid arthritis, granulomatous vasculitis, systemic lupus erythematosus, ankylosing spondylitis, and gout (OR = 2.93, 95% CI = 2.66-3.23; OR = 7.37, 95% CI = 3.91-13.88; OR = 3.18, 95% CI = 2.63-3.85; OR = 5.57, 95% CI = 4.99-6.22; OR = 2.84, 95% CI = 2.72-2.96, respectively). The results strongly support an association between Sjogren syndrome, post ocular surgery, systemic infection disease, systemic autoimmune disease, and scleritis.
Relation:	JOURNAL OF PERSONALIZED MEDICINE, v.12, n.1, 105
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

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