Comparing different surface modifications of zinc oxide nanoparticles in the developmental toxicity of zebrafish embryos and larvae

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標題:	Comparing different surface modifications of zinc oxide nanoparticles in the developmental toxicity of zebrafish embryos and larvae
作者:	Chen, Zi-Yu Yang, Yi-Chun Wang, Bour-, Jr. Cheng, Fong-Yu Lee, Yen-Ling Lee, Yu-Hsuan Wang, Ying-Jan
貢獻者:	National Cheng Kung University National Cheng Kung University National Cheng Kung University Hospital Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy & Science Chinese Culture University China Medical University Taiwan China Medical University Taiwan China Medical University Hospital - Taiwan China Medical University Taiwan National Cheng Kung University
關鍵字:	toxicology systems metal
日期:	2022
上傳時間:	2023-12-11 13:58:48 (UTC+8)
出版者:	ACADEMIC PRESS INC ELSEVIER SCIENCE
摘要:	Nanotechnology allows for a greater quality of life, but may also cause environmental and organismic harm. Zinc oxide nanoparticles (ZnONPs) are one of the most commonly used metal oxide nanoparticles for commercial and industrial products. Due to its extensive use in various fields, there has already been much concern raised about the environmental health risks of ZnONPs. Many studies have investigated the toxicological profile of ZnONPs in zebrafish embryonic development; however, the specific characteristics of ZnONPs in zebrafish embryonic/larval developmental damage and their molecular toxic mechanisms of liver development are yet to be fully elucidated. This study aimed to reveal the hazard ranking of different surface modifications of ZnONPs on developing zebrafish and the toxicological mechanisms of these modified ZnONPs in liver tissue. The similar to 30 nm ZnONPs with amino-(NH2-ZnONPs) or carboxyl-(COOH-ZnONPs) modification were incorporated during the embryonic/larval stage of zebrafish. Severe toxicity was observed in both ZnONP groups, especially NH2-ZnONPs, which presented a higher toxicity in the low concentration groups. After prolonging the exposure time, the long-term toxicity assay showed a greater retardation in body length of zebrafish in the NH2-ZnONP group. Response data from multiple toxicity studies was integrated for the calculation of the EC50 values of bulk ZnO and ZnONPs, and the hazard levels were found to be decreasing in the order of NH2-, COOH-ZnONPs and bulk ZnO. Notably, NH2-ZnONPs induced ROS burden in the developing liver tissue, which activated autophagy-related gene and protein expression and finally induced liver cell apoptosis to reduce liver size. In conclusion, our findings are conducive to understanding the hazard risks of different surface modifications of ZnONPs in aquatic environments and will also be helpful for choosing the type of ZnONPs in future industrial applications.
關聯:	ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v.243, 113967
显示于类别:	[化妝品應用與管理系(所)] 期刊論文

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