Preoperative Apparent Diffusion Coefficient Values for Differentiation between Low and High Grade Meningiomas: An Updated Systematic Review and Meta-Analysis

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標題:	Preoperative Apparent Diffusion Coefficient Values for Differentiation between Low and High Grade Meningiomas: An Updated Systematic Review and Meta-Analysis
作者:	Tsai, Yueh-Ting Hung, Kuo-Chuan Shih, Yun-Ju Lim, Sher-Wei Yang, Cheng-Chun Kuo, Yu-Ting Chen, Jeon-Hor Ko, Ching-Chung
貢獻者:	Chi Mei Hospital Chi Mei Hospital Chia Nan University of Pharmacy & Science Chi Mei Hospital Kaohsiung Medical University Kaohsiung Medical University Hospital University of California System University of California Irvine I Shou University E-Da Hospital Chia Nan University of Pharmacy & Science National Sun Yat Sen University
關鍵字:	atypical meningiomas histological-subtypes malignant meningiomas brain-tumors mri benign classification index
日期:	2022
上傳時間:	2023-12-11 13:58:15 (UTC+8)
出版者:	MDPI
摘要:	The meta-analysis aimed to compare the preoperative apparent diffusion coefficient (ADC) values between low-grade meningiomas (LGMs) and high-grade meningiomas (HGMs). Medline, Cochrane, Scopus, and Embase databases were screened up to January 2022 for studies investigating the ADC values of meningiomas. The study endpoint was the reported ADC values for LGMs and HGMs. Further subgroup analyses between 1.5T and 3T MRI scanners, ADC threshold values, ADC in different histological LGMs, and correlation coefficients (r) between ADC and Ki-67 were also performed. The quality of studies was evaluated by the quality assessment of diagnostic accuracy studies (QUADAS-2). A chi 2-based test of homogeneity was performed using Cochran's Q statistic and inconsistency index (I-2). Twenty-five studies with a total of 1552 meningiomas (1102 LGMs and 450 HGMs) were included. The mean ADC values (x10(-3) mm(2)/s) were 0.92 and 0.79 for LGMs and HGMs, respectively. Compared with LGMs, significantly lower mean ADC values for HGMs were observed with a pooled difference of 0.13 (p < 0.00001). The results were consistent in both 1.5T and 3T MRI scanners. For ADC threshold values, pooled sensitivity of 69%, specificity of 82%, and AUC of 0.84 are obtained for differentiation between LGMs and HGMs. The mean ADC (x10(-3) mm(2)/s) in different histological LGMs ranged from 0.87 to 1.22. Correlation coefficients (r) of mean ADC and Ki-67 ranged from -0.29 to -0.61. Preoperative ADC values are a useful tool for differentiating between LGMs and HGMs. Results of this study provide valuable information for planning treatments in meningiomas.
關聯:	DIAGNOSTICS, v.12, n.CB2, pp.CC2, pp.-,
顯示於類別:	[行政單位] 123

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