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| 標題: | Risk of Stroke in Patients with Breast Cancer and Sleep Disorders |
| 作者: | Chen, Nan-Cheng
Liao, Kuang-Ming
Tian, Yu-Feng
Wu, Yu-Cih
Wang, Jhi-Joung
Ho, Chung-Han
Hsu, Chien-Chin |
| 貢獻者: | Chi Mei Med Ctr, Dept Internal Med
Southern Taiwan Univ Sci & Technol, Dept Biotechnol & Food Technol
Chi Mei Med Ctr, Div Gastroenterol & Gen Surg
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Chi Mei Med Ctr, Dept Med Res
Chi Mei Med Ctr, Dept Anesthesiol
Natl Def Med Ctr, Dept Anesthesiol
Southern Taiwan Univ Sci & Technol, Dept Informat Management
Taipei Med Univ, Wan Fang Hosp, Canc Ctr
Chi Mei Med Ctr, Dept Emergency Med |
| 關鍵字: | CARDIOVASCULAR EVENTS
TAIWAN |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:59:52 (UTC+8) |
| 出版者: | IVYSPRING INT PUBL |
| 摘要: | Breast cancer and stroke were leading cause of cancer-related mortality in the world. Stroke is the second leading cause of death. Previous studies showed that patients with breast cancer had a relatively higher risk of sleep disorders. Sleep disorders increased the risk of stroke. The aim of our study was to examine the risk of stroke after a breast cancer with sleep disorder among women in Taiwan. The Taiwan Cancer Registry was used to identify patients with breast cancer. Patients with new-onset breast cancer from January 2007 to December 2015 were selected for this study and followed until December 31, 2017. Patients who were diagnosed with sleep disorders were set as the case group, and the controls were those without sleep disorders. We enrolled 5256 patients with sleep disorders and 10,512 patients without sleep disorders. There were 121 (2.30%) patients with ischemic stroke among the breast cancer patients with sleep disorders. The mean time from the diagnosis of breast cancer to the occurrence of ischemic stroke was 6.29 +/- 2.59 years for breast cancer patients with sleep disorders and 6.00 +/- 2.76 years for those without sleep disorders (p < 0.0001). After matching by age and index year, breast patients with sleep disorders had a 1.31-fold higher risk (95% confidence interval: 1.03-1.66; p-value=0.026) of ischemic stroke than those without sleep disorders, after adjustment for comorbidities, cancer clinical stage, and treatment types. In conclusion, Breast cancer patients with sleep disorders have an increased risk of stroke. |
| 關聯: | J CANCER, v.12, n.22, pp.6749-6755 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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