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| 標題: | Bilateral oophorectomy and the risk of hepatocellular carcinoma in women with hepatitis C: A population-based study |
| 作者: | Chen, Chao-Yu
Wang, Ting-Yao
Chen, Wei-Ming
Chen, Kai-Hua
Yang, Yao-Hsu
Chen, Pau-Chung
Chen, Vincent Chin-Hung |
| 貢獻者: | Chang Gung Mem Hosp, Dept Obstet & Gynecol
Chang Gung Mem Hosp, Dept Internal Med, Div Hematol & Oncol
Chang Gung Mem Hosp, Dept Internal Med, Div Gastroenterol & Hepatol
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Chang Gung Univ, Coll Med, Sch Med
Chang Gung Mem Hosp, Dept Phys Med & Rehabil
Chang Gung Mem Hosp, Hlth Informat & Epidemiol Lab
Chang Gung Mem Hosp, Dept Tradit Chinese Med
Chang Gung Univ, Coll Med, Sch Tradit Chinese Med
Natl Taiwan Univ, Coll Publ Hlth, Inst Environm & Occupat Hlth Sci
Natl Taiwan Univ, Coll Publ Hlth, Dept Publ Hlth
Natl Taiwan Univ Hosp, Dept Environm & Occupat Med
Natl Taiwan Univ, Coll Med
Natl Taiwan Univ Hosp, Off Occupat Safety & Hlth, Taipei, Taiwan;[Chen, Vincent Chin-Hung
Chang Gung Mem Hosp, Dept Psychiat, Puzi City
Chang Gung Univ |
| 關鍵字: | Hepatitis C virus
Hepatocellular carcinoma
Oophorectomy
National Health Insurance Research Database |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:56:49 (UTC+8) |
| 出版者: | ELSEVIER IRELAND LTD |
| 摘要: | Objective: Patients with chronic hepatitis C virus (HCV) infection are at high risk of developing hepatocellular carcinoma (HCC). Previous studies suggested that menopause may increase the risk of HCC. We investigated the association between bilateral oophorectomy (BO) and the risk of HCC in women with HCV infection. Study design: We used data from the National Health Insurance Research Database of Taiwan and conducted a matched cohort study. Main outcome measures: The main outcome was HCC. We used a competing risk model to adjust for potential confounding factors. Results: From 1997-2013, we identified 2176 patients with BO and 8704 controls. A total of 107 HCC cases (4.9 %, 107/2176) were identified in the BO group compared with 465 HCC cases (5.3 %, 465/8704) in the control group. The incidence rates were 506.3 and 538.9 cases per 100,000 person-years among the HCV-infected pa-tients with and without BO, respectively. The competing risk model showed that BO did not increase the risk of developing HCC. Furthermore, a sub-analysis of only women under 50 years of age similarly showed that BO did not increase the risk of developing HCC after adjusting for additional covariates. The log-rank test revealed that whether or not the patients had received HRT, patients with BO did not have an increased risk of developing HCC (non-BO vs BO with HRT, p = 0.10; non-BO vs BO without HRT, p = 0.09). The use of HRT after BO did not influence the risk of developing HCC. Conclusions: This study examined a large dataset with a long follow-up period to test the relationship between BO and the risk of HCC in HCV-infected women. Our findings suggest that BO did not increase the risk of HCC, regardless of HRT usage, in these women. |
| 關聯: | MATURITAS, v.146, pp.11-17 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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