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| 標題: | Antimalarial primaquine for skin infiltration analgesia in rats |
| 作者: | Chang, Ying-Jen
Liu, Kuo-Sheng
Wang, Jhi-Joung
Chen, Yu-Wen
Hung, Ching-Hsia |
| 貢獻者: | Chi Mei Med Ctr, Dept Anesthesiol
Chang Jung Christian Univ, Coll Hlth Sci
Chia Nan Univ Pharm & Sci, Dept Pharm
Chi Mei Med Ctr, Dept Med Res
Southern Taiwan Univ Sci & Technol, Allied AI Biomed Ctr
China Med Univ, Coll Hlth Care, Dept Phys Therapy
Natl Cheng Kung Univ, Coll Med, Dept Phys Therapy
Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci |
| 關鍵字: | primaquine
lidocaine
antimalarial drugs
skin infiltration anaesthesia |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:56:29 (UTC+8) |
| 出版者: | OXFORD UNIV PRESS |
| 摘要: | Objectives The purpose of this study was to estimate the ability of antimalarial medications to induce local infiltration analgesia. Methods Using a rat model of skin infiltration anaesthesia, the effects of antimalarial medications (primaquine, chloroquine, hydroxychloroquine and amodiaquine) were compared with the application of lidocaine. Key findings At a dose of 3 mu mol, primaquine and chloroquine displayed better potency (all P < 0.05) and greater duration (all P < 0.01) of cutaneous analgesia than lidocaine, whereas the other antimalarial medications showed a similar potency and duration of cutaneous analgesia when compared with lidocaine. When a dose of 3 mu mol antimalarial medication was used, primaquine was the most potent and had the longest duration of action among four antimalarial medications. The relative potency ranking (ED50, 50% effective dose) has been found to be primaquine [2.10 (1.87 - 2.37) mu mol] > lidocaine [6.27 (5.32 -7.39) mu mol] (P < 0.01). Infiltration analgesia of skin with primaquine had a greater duration of action than did lidocaine on the equipotent (ED25, ED50, ED75) basis (P < 0.01). Conclusions Primaquine and chloroquine have greater potency and longer lasting skin analgesia when compared with lidocaine, while the other antimalarials display a similar potency in comparison with lidocaine. |
| 關聯: | J PHARM PHARMACOL, v.73, n.2, pp.206-211 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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