The risk of pulmonary tuberculosis after traumatic brain injury

doi:10.1038/s41598-021-87332-6

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標題:	The risk of pulmonary tuberculosis after traumatic brain injury
作者:	Liu, Hsin-Yueh Liao, Kuang-Ming Liang, Fu-Wen Hung, Yi-Chieh Wang, Jhi-Joung Shen, Te-Chun Ho, Chung-Han
貢獻者:	Chi Mei Med Ctr, Dept Internal Med Kaohsiung Med Univ, Coll Hlth Sci, Dept Publ Hlth Kaohsiung Med Univ Hosp, Dept Med Res Kaohsiung Med Univ, Res Ctr Environm Med Chi Mei Med Ctr, Dept Surg, Dept Neurosurg Chia Nan Univ Pharm & Sci, Dept Recreat & Healthcare Management Chi Mei Med Ctr, Dept Med Res Chi Mei Med Ctr, Dept Anesthesiol Southern Taiwan Univ Sci & Technol, AI Biomed Ctr China Med Univ, Sch Med China Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med
日期:	2021
上傳時間:	2023-11-11 11:52:49 (UTC+8)
出版者:	NATURE RESEARCH
摘要:	After traumatic brain injury (TBI), an inflammatory response in the brain might affect the immune system. The risk of pulmonary infection reportedly increases in patients with TBI. We aimed to evaluate the risk of tuberculosis (TB) in patients with TBI in Taiwan. All participants were selected from the intensive care unit (ICU). Patients with TBI were defined as patients in ICU with intracranial injury, and comparison cohort were patients in ICU without TBI diagnosis. There was a significant difference in TB risk between the patients with TBI and the comparison cohort according to age and the Charlson's comorbidity index (CCI) score. Thus, we divided patients based on CCI into three groups for further analysis: mild (CCI = 0), moderate (CCI = 1/2), severe (CCI > 2). Mild-CCI group had a lower TB incidence rate (0.74%) and longer time to TB development (median: 2.43) than the other two groups. Moderate-CCI group had 1.52-fold increased risk of TB infection (p < 0.0001) compared with mild-CCI group. In the severe-CCI group, patients aged >= 80 years had 1.91-fold risk of TB compared with mild-CCI group (p = 0.0481). Severe-CCI group had significantly higher mortality than the mild-CCI group (p = 0.0366). Patients with TBI and more comorbidities had higher risk of TB infection with higher mortality rate.
關聯:	SCI REP-UK, v.11, n.1, pp.7840
显示于类别:	[休閒保健管理系(所)] 期刊論文

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