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| 標題: | Neurodevelopment regulators miR-137 and miR-34 family as biomarkers for early and adult onset schizophrenia |
| 作者: | Chen, Bao-Yu
Lin, Jin-Jia
Lu, Ming-Kun
Tan, Hung-Pin
Jang, Fong-Lin
Lin, Sheng-Hsiang |
| 貢獻者: | Natl Cheng Kung Univ, Coll Med, Inst Clin Med
Chi Mei Med Ctr, Dept Psychiat
Jianan Mental Hosp, Dept Hlth
Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth
Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth
Natl Cheng Kung Univ, Coll Med, Dept Publ Hlth
Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med |
| 關鍵字: | NEURAL DEVELOPMENT
MICRORNA
DISORDERS
VARIANT
PATHOPHYSIOLOGY
DYSREGULATION
ASSOCIATION
RELATIVES
SYMPTOMS
INSIGHTS |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:49:29 (UTC+8) |
| 出版者: | NATURE RESEARCH |
| 摘要: | Early-onset schizophrenia (EOS) may have stronger familial aggregation and a more severe outcome than adult-onset schizophrenia (AOS). MicroRNA (miRNA) takes on dual roles as a genetic and epigenetic modulator, which may mediate the influence of genetic risk. Neurological soft signs (NSS) are neurological abnormalities that may be intermediate phenotypes or endophenotypes for schizophrenia. Our previous study found poorer performance on NSS tests from patients with EOS and their unaffected first-degree relatives. Thus, we aimed to identify a set of aberrant neurodevelopmental-related miRNAs that could serve as potential biomarkers for EOS or schizophrenia with NSS. This study included 215 schizophrenia patients (104 EOS and 111 AOS), 72 unaffected first-degree relatives, 31 patients with bipolar disorder, and 100 healthy controls. Differential expression analysis revealed that miR-137, miR-34b, and miR-34c were significantly up-regulated in patients with schizophrenia and their unaffected first-degree relatives compared to healthy controls. Receiver operating characteristic (ROC) analysis showed that the miR-137 expression signature could be used to discriminate between patients with EOS and healthy controls (AUC = 0.911). Additionally, miR-34b had the highest ability to discriminate between EOS and AOS (AUC = 0.810), which may indicate different aetiological pathways to disease onset. Moreover, miR-137 dysregulation was correlated with almost all NSS subscales (i.e., sensory integration, motor sequencing, etc.) and, when EOS patients with NSS, miR-137 expression discriminated these patients from healthy controls to a greater extent (AUC = 0.957). These findings support the potential for neurodevelopmental-related miRNAs to be used as indicators of vulnerability to EOS. |
| 關聯: | NPJ SCHIZOPHR, v.7, n.1 |
| 顯示於類別: | [生活保健科技系] 期刊論文
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