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| 標題: | Prognostic Significance of ROR2 Expression in Patients with Urothelial Carcinoma |
| 作者: | Yeh, Cheng-Fa
Chan, Ti-Chun
Ke, Hung-Lung
Chen, Tzu-Ju
Wu, Li-Ching
Lee, Hsiang-Ying
Wei, Yu-Ching
Wu, Wen-Jeng
Li, Chien-Feng
Li, Wei-Ming |
| 貢獻者: | Chi Mei Med Ctr, Div Gen Internal Med
Chia Nan Univ Pharm & Sci, Dept Environm Engn & Sci
Chi Mei Med Ctr, Dept Med Res
Natl Hlth Res Inst, Natl Inst Canc Res
Kaohsiung Med Univ Hosp, Dept Urol
Kaohsiung Med Univ, Coll Med, Sch Med, Dept Urol
Kaohsiung Municipal Tatung Hosp, Dept Urol
Chi Mei Med Ctr, Dept Clin Pathol
Kaohsiung Med Univ, Coll Med, Sch Med, Dept Pathol
Kaohsiung Municipal Tatung Hosp, Dept Pathol
Kaohsiung Med Univ, Ctr Liquid Biopsy & Cohort Res
Minist Hlth & Welf Pingtung Hosp, Dept Urol |
| 關鍵字: | ROR2
bladder cancer
upper tract urothelial carcinoma
survival
prognosis |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:48:49 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | We investigated the association of receptor tyrosine kinase-like orphan receptor 2 (ROR2) expression with clinicopathological features and oncologic outcomes in large urothelial carcinoma (UC) of the upper tract (UTUC) and urinary bladder (UBUC) cohorts. Through transcriptomic profiling of a published dataset (GSE31684), ROR2 was discovered to be the most upregulated gene during UC progression, focusing on the INK cascade (GO:0007254). Initially, the evaluation of ROR2 mRNA expression in 50 frozen UBUCs showed significantly upregulated levels in highstage UC. Moreover, high ROR2 immunoexpression significantly correlated with high tumor stage, high tumor grade, lymph node metastasis, and vascular invasion (all p < 0.05). In multivariate analysis, after adjusting for standard clinicopathological features, ROR2 expression status was an independent prognosticator of cancer-specific survival and metastasis-free survival in UTUC and UBUC (all p < 0.01). In the subgroup analysis, it also significantly predicted bladder tumor recurrence in non-muscle invasive UBUC. Furthermore, the GO enrichment analysis showed that fatty acid, monocarboxylic acid, carboxylic acid metabolic processes, negative regulation of neutrophil migration, and negative regulation of granulocyte and neutrophil chemotaxis were significantly enriched by ROR2 dysregulation. In conclusion, high ROR2 immunoexpression was associated with aggressive pathological characteristics in UC and independently predicted worse prognosis, suggesting it could play roles in clinical risk stratification and therapy decisions. |
| 關聯: | BIOMEDICINES, v.9, n.8 |
| 顯示於類別: | [環境工程與科學系(所)] 期刊論文
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