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| 標題: | Constitutive Cytomorphologic Features of Medullary Thyroid Carcinoma Using Different Staining Methods |
| 作者: | Liu, Chih-Yi
Chen, Chien-Chin
Bychkov, Andrey
Agarwal, Shipra
Zhu, Yun
Hang, Jen-Fan
Lai, Chiung-Ru
Na, Hee Young
Park, So Yeon
Li, Weiwei
Liu, Zhiyan
Jain, Deepali
Suzuki, Ayana
Hirokawa, Mitsuyoshi
Chia, Noel
Nga, Min En
Jitpasutham, Tikamporn
Keelawat, Somboon
Satoh, Shinya
Gunawardena, Dilini
Kumarasinghe, Priyanthi
Jung, Chan Kwon
Kakudo, Kennichi |
| 貢獻者: | Sijhih Cathay Gen Hosp, Div Pathol
Fu Jen Catholic Univ, Coll Med, Sch Med
Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Pathol
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Kameda Med Ctr, Dept Pathol, Kamogawa
Nagasaki Univ, Dept Pathol, Grad Sch Biomed Sci
All India Inst Med Sci, Dept Pathol
Jiangsu Inst Nucl Med, Dept Pathol
Taipei Vet Gen Hosp, Dept Pathol & Lab Med
Natl Yang Ming Chiao Tung Univ, Sch Med
Seoul Natl Univ, Coll Med, Dept Pathol, Bundang Hosp
Shandong Univ, Dept Pathol, Sch Basic Med Sci
Shanghai Jiao Tong Univ, Dept Pathol
Kuma Hosp, Dept Diagnost Pathol & Cytol, Kobe, Hyogo 6500011, Japan;[Chia, Noel;Nga, Min En
Natl Univ Singapore Hosp, Dept Pathol
Chulalongkorn Univ, Fac Med, Dept Pathol
Yamashita Thyroid & Parathyroid Clin, Dept Endocrine Surg
Univ Western Australia, Sch Pathol & Lab Med, Perth
Catholic Univ Korea, Dept Hosp Pathol, Coll Med
Izumi City Gen Hosp, Dept Pathol & Thyroid Dis Ctr, Izumi |
| 關鍵字: | cytology
fine-needle aspiration
medullary thyroid carcinoma
sensitivity
specificity
thyroid |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:48:39 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | (1) Background: Accurate preoperative identification of medullary thyroid carcinoma (MTC) is challenging due to a spectrum of cytomorphologic features. However, there is a scarcity of studies describing the cytomorphologic features as seen on fine-needle aspiration (FNA) smears prepared using different staining methods. (2) Methods: We performed a retrospective study on MTC cases with available FNA slides from 13 hospitals distributed across 8 Asia-Pacific countries. The differences in the constitutive cytomorphologic features of MTC with each cytopreparatory method were recorded. A comparative analysis of cytologic characteristics was carried out with appropriate statistical tests. (3) Results: Of a total of 167 MTC samples retrospectively recruited, 148 (88.6%) were interpreted as MTC/suspicious for MTC (S-MTC). The staining methods used were Papanicolaou, hematoxylin-eosin, and Romanowsky stains. Seven out of the eleven cytologic criteria can be readily recognized by all three cytopreparatory methods: high cellularity, cellular pleomorphism, plasmacytoid cells, round cells, dyshesive cells, salt-and-pepper chromatin, and binucleation or multinucleation. An accurate diagnosis was achieved in 125 (84.5%) of the 148 samples whose FNAs exhibited five or more atypical features. Conclusions: The present work is the first study on MTC to compare the morphological differences among the cytologic staining techniques. We investigated the constitutive features and the reliability of diagnostic parameters. A feasible scoring system based upon cytomorphologic data alone is proposed to achieve a high degree of diagnostic accuracy. |
| 關聯: | DIAGNOSTICS, v.11, n.8 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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