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請使用永久網址來引用或連結此文件:
https://ir.cnu.edu.tw/handle/310902800/34142
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| 標題: | Effects of Sclareol Against Small Cell Lung Carcinoma and the Related Mechanism: In Vitro and In Vivo Studies |
| 作者: | Chen, Hsiang Lai
Gong, Jiny Yin
Lin, Shih-Chao
Li, Shiming
Chiang, Yu-Chih
Hung, Jui-Hsiang
Yen, Chieh-Chi
Lin, Chi-Chien |
| 貢獻者: | Tungs Taichung MetroHarbor Hosp, Div Urol, Dept Surg
Natl Chung Hsing Univ, PhD Program Translat Med
Natl Chung Hsing Univ, Inst Biomed Sci, IEGG & Anim Biotechnol Ctr
Natl Taiwan Ocean Univ, Bachelor Degree Program Marine Biotechnol, Coll Life Sci,
Virginia Polytech Inst & State Univ, Dept Biomed & Pathobiol, Blacksburg
Huanggang Normal Univ, Coll Chem & Chem Engn, Hubei Key Lab Proc & Applicat Catalyt Mat
Fu Jen Catholic Univ, Coll Human Ecol, Dept Restaurant Hotel & Inst Management
Chia Nan Univ Pharm & Sci, Dept Biotechnol
Changhua Christian Hosp, Dept Radiol, Changhua Christian Med
China Med Univ Hosp, Dept Med Res
Taichung Vet Gen Hosp, Dept Med Res |
| 關鍵字: | Small cell lung carcinoma
Sclareol
cell cycle
apoptosis
DNA damage
xenograft |
| 日期: | 2020 |
| 上傳時間: | 2022-11-18 11:25:45 (UTC+8) |
| 出版者: | Int Inst Anticancer Research |
| 摘要: | Background/Aim: This study aimed to investigate the anticancer effects and potential mechanisms of sclareol in a human small cell lung carcinoma (SCLC) cell line. Materials and Methods: Cell viability was determined by the MIT assay. Cell cycle, apoptosis and caspase activity were evaluated by flow cytometry. Cell cycle and DNA damage related protein expression was determined by western blotting. In vivo evaluation of sclareol was carried out in xenografted tumor mice models. Results: Sclareol significantly reduced cell viability, induced G(1) phase arrest and subsequently triggered apoptosis in H1688 cells. In addition, this sclareol-induced growth arrest was associated with DNA damage as indicated by phosphorylation of H2AX, activation of ATR and Chk1. Moreover, in vivo evaluation of sclareol showed that it could inhibit tumor weight and volume in a H1688 xenograft model. Conclusion: Sclareol might be a novel and effective therapeutic agent for the treatment of SCLC patients. |
| 關聯: | Anticancer Research, v.40, n.9, pp.14 |
| 顯示於類別: | [生物科技系(所)] 期刊論文
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