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| 標題: | Cytologic diagnosis of medullary thyroid carcinoma in theAsia-Pacificregion |
| 作者: | Liu, Chih-Yi
Bychkov, Andrey
Agarwal, Shipra
Zhu, Yun
Hang, Jen-Fan
Lai, Chiung-Ru
Na, Hee Young
Li, Weiwei
Liu, Zhiyan
Jain, Deepali
Suzuki, Ayana
Hirokawa, Mitsuyoshi
Chia, Noel
Nga, Min En
Jitpasutham, Tikamporn
Keelawat, Somboon
Park, So Yeon
Satoh, Shinya
Chen, Chien-Chin
Gunawardena, Dilini
Kumarasinghe, Priyanthi
Jung, Chan Kwon
Kakudo, Kennichi |
| 貢獻者: | Sijhih Cathay Gen Hosp, Div Pathol
Kameda Med Ctr, Dept Pathol, Kamogawa
Nagasaki Univ, Dept Pathol, Grad Sch Biomed Sci, Nagasaki
All India Inst Med Sci, Dept Pathol
Jiangsu Inst Nucl Med, Dept Pathol
Taipei Vet Gen Hosp, Dept Pathol & Lab Med
Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Pathol, Seongnam
Shandong Univ, Dept Pathol, Sch Basic Med Sci
Kuma Hosp, Dept Diagnost Pathol & Cytol
Natl Univ Singapore Hosp, Dept Pathol
Chulalongkorn Univ, Dept Pathol, Fac Med
Yamashita Thyroid & Parathyroid Clin, Dept Endocrine Surg,
Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Pathol
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Univ Western Australia, Sch Pathol & Lab Med
Catholic Univ Korea, Dept Hosp Pathol, Coll Med
Izumi City Gen Hosp, Dept Pathol & Thyroid Dis Ctr |
| 關鍵字: | Asia-Pacific
fine needle aspiration cytology
medullary thyroid carcinoma
sensitivity and specificity
thyroid |
| 日期: | 2021 |
| 上傳時間: | 2022-11-18 11:24:57 (UTC+8) |
| 出版者: | Wiley |
| 摘要: | Background The accurate preoperative identification of medullary thyroid carcinoma (MTC) is challenging due to the rarity of tumor and variable cytologic appearance. The Asian experience with diagnosing MTC by fine-needle aspiration (FNA) was scarcely reported. Methods Cases of MTC with available FNA slides were enrolled from 13 hospitals representing 8 Asia-Pacific countries. Clinicopathological information, including sample preparation technique, staining method, original cytologic diagnosis and review diagnosis were collected. Results Of a total of 145 MTC cases retrospectively recruited, 99 (68.3%) were initially interpreted as MTC/suspicious for MTC (S-MTC). The distribution of original FNA diagnostic categories was not associated with the staining method or sample preparation technique. The staining methods used were Papanicolaou, hematoxylin-eosin and Romanowsky stains. Liquid-based cytology (LBC) was used only in three countries. After reviewing all cases, the diagnostic rate of MTC/S-MTC increased to 91.7% (133/145). Cases with initially unrecognized MTC had either marked pleomorphism or cytology mimicking papillary carcinoma or follicular neoplasm. Although LBC provided certain benefits, there was no significant difference in diagnostic accuracy between conventional smear and LBC. Immunocytochemistry was available in 38 cases (26.2%), all of which were correctly recognized as MTC. Conclusion Our report summarizes how MTC is handled in contemporary Asian thyroid FNA practice. Although the detection rate of MTC by cytology alone is less satisfactory, integration with ancillary tests could achieve an excellent performance. The recognition of constitutive cytomorphologic features is needed for each cytopreparatory method, which may result in a lower threshold to initiate further workup for MTC. |
| 關聯: | Diagnostic Cytopathology, v.49, n.1, pp.10 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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