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| 標題: | Chronic Pain Increases the Risk for Major Adverse Cardiac and Cerebrovascular Events: A Nationwide Population-Based Study in Asia |
| 作者: | Chung, Kun-Ming
Ho, Chung-Han
Chen, Yi-Chen
Hsu, Chien-Chin
Chiu, Chong-Chi
Lin, Hung-Jung
Wang, Jhi-Joung
Huang, Chien-Cheng |
| 貢獻者: | Chi Mei Med Ctr, Dept Internal Med, Div Gen Internal Med
Chia Nan Univ Pharm & Sci, Dept Recreat & Hlth Care Management
Chi Mei Med Ctr, Dept Med Res
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
Chi Mei Med Ctr, Dept Emergency Med
Southern Taiwan Univ Sci & Technol, Dept Biotechnol
Chi Mei Med Ctr, Dept Gen Surg
Southern Taiwan Univ Sci & Technol, Dept Elect Engn
Taipei Med Univ, Dept Emergency Med
Southern Taiwan Univ Sci & Technol, Dept Senior Serv
Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth |
| 關鍵字: | Asian
Cardiac
Cerebrovascular
Chronic Pain
Death
Mortality |
| 日期: | 2020 |
| 上傳時間: | 2022-11-18 11:24:04 (UTC+8) |
| 出版者: | Oxford Univ Press |
| 摘要: | Objective. Chronic pain (CP) may increase the risk for major adverse cardiac and cerebrovascular events (MACCEs); however, this issue is still unclear in the Asian population. We conducted this study to delineate it. Design. From the Taiwan National Health Insurance Research Database, we identified 17,614 participants (<65 years) with CP and matched them by age and sex at a 1:2 ratio to participants without CP, who made up the comparison cohort. Several causes of CP and its underlying comorbidities were also analyzed. Outcome Measure. A comparison of MACCE occurring in the two cohorts was performed via follow-up until 2015. Results. The mean age (SD) was 50.2 (11.5) years and 50.4 (11.7) years in participants with and without CP, respectively. In both cohorts, the percentage of female participants was 55.5%. Common causes of CP were spinal disorders (23.9%), osteoarthritis (12.4%), headaches (11.0%), gout (10.2%), malignancy (6.2%), and osteoporosis (4.5%). After adjusting for hypertension, diabetes, chronic obstructive pulmonary disease, renal diseases, hyperlipidemia, liver diseases, dementia, and depression, participants with CP had a higher risk for MACCE than those without CP (adjusted hazard ratio [AHR] = 1.3, 95% confidence interval [CI] = 1.3 - 1.4). After conducting subgroup analyses, an increased risk was also found for all-cause mortality (AHR = 1.4, 95% CI = 1.1 - 1.8), acute myocardial infarction (AHR = 1.2, 95% CI = 1.0 - 1.4), and stroke (AHR = 1.3, 95% CI = 1.3 - 1.4). Conclusions. CP is associated with increased occurrence of MACCE. Early detection and interventions for CP are suggested. |
| 關聯: | Pain Medicine, v.21, n.9, pp.6 |
| 顯示於類別: | [休閒保健管理系(所)] 期刊論文
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