新穎型防曬劑合成與研究

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Dissertations and Theses > Item 310902800/33077

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/33077

Title:	新穎型防曬劑合成與研究 Synthesis and research of novel sunscreens
Authors:	涂承恩
Contributors:	化粧品應用與管理系楊朝成何文岳
Keywords:	防曬毒性高分子聚合物紫外線 sunscreen toxicity high molecular weight ultraviolet light
Date:	2019
Issue Date:	2020-12-09 14:46:30 (UTC+8)
Abstract:	本研究主要是以化學防曬劑Benzophenone-1、Benzophenone-3為起始物，經過帶有雙鍵官能基的修飾，得到具有雙鍵可聚合的中間產物，再利用中間產物跟偶氮二異丁腈 (AIBN) 進行自由基聚合反應，得到高分子防曬聚合物。探討高分子防曬劑之紫外線吸收、毒性測試，應用於防曬化粧品中，減少經皮吸收，以提升化學防曬產品的安全性。進行高分子聚合物過程中，AIBN的添加量會影響聚合分子量大小的關鍵，透過不同的當量數可以觀察到，當量數越小，聚合物的分子量越大。化學結構改變，對紫外線吸收的變化也是一大關鍵，實驗過程中，我們發現如果原本帶有兩個羥基的防曬起始物都接上雙鍵的官能基，會導致藍位移，反之，當苯環上還留有一個羥基時，則保持與起始物一樣的紫外線波長範圍。除此之外，透過細胞毒性測試來檢驗發現在濃度500 ng/ml時，Benzophenone-1會顯著的抑制細胞生長(72±5%)，而高分子聚合物則無明顯抑制細胞生長。 In this study, the chemical sunscreen agents Benzophenone-1 and Benzophenone-3 were used as the starting materials. After modification with a double bond functional group, an intermediate product with double bond polymerizable was obtained, and the intermediate product was used with azobisisoindole. The nitrile (AIBN) is subjected to radical polymerization to obtain a polymer sunscreen polymer. Explore the UV absorption and toxicity test of polymer sunscreens, apply them to sunscreen cosmetics, reduce percutaneous absorption, and improve the safety of chemical sunscreen products. In the process of polymer, the amount of AIBN added will affect the molecular weight of the polymer. It can be observed by different number of equivalents. The smaller the number of equivalents, the larger the molecular weight of the polymer. The change of chemical structure is also a key to the change of UV absorption. During the experiment, we found that if the sunscreen starting material with two hydroxyl groups is connected to the functional group of the double bond, it will cause blue shift, and vice versa. When a hydroxyl group remains on the ring, the same ultraviolet wavelength range as the starting material is maintained. In addition, by cytotoxicity test, Benzophenone-1 significantly inhibited cell growth (72±5%) at a concentration of 500 ng/ml, while high molecular weight did not significantly inhibit cell growth.
Relation:	電子全文公開日期：2024-09-04 學年度：107，90頁
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Dissertations and Theses

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	688	View/Open

Loading...