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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32709


    標題: Chlorpheniramine produces cutaneous analgesia in rats
    作者: Chiu, Chong-Chi
    Kuo-Sheng Liu(劉國盛)
    Chen, Yu-Wen
    Hung, Ching-Hsia
    Wang, Jhi-Joung
    貢獻者: Chi Mei Med Ctr, Dept Gen Surg
    Southern Taiwan Univ Sci & Technol, Dept Elect Engn
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Chi Mei Med Ctr, Dept Med Res
    China Med Univ, Coll Hlth Care, Dept Phys Therapy
    Natl Cheng Kung Univ, Coll Med, Dept Phys Therapy, 1 Ta Hsueh Rd
    Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci
    Southern Taiwan Univ Sci & Technol, Allied AI Biomed Ctr
    關鍵字: Chlorpheniramine
    Bupivacaine
    Infiltrative cutaneous analgesia
    Needle pinprick
    日期: 2019-08
    上傳時間: 2020-08-25 15:07:45 (UTC+8)
    出版者: SPRINGER HEIDELBERG
    摘要: Background This study sought to assess the cutaneous (peripheral) analgesic effects of antihistamine chlorpheniramine, compared with the long-lasting local anesthetic bupivacaine. Methods After chlorpheniramine and bupivacaine were subcutaneously injected under the dorsal skin of the rats, the cutaneous analgesia effect was quantitatively evaluated by scoring the number to which the animal failed to react (cutaneous trunci muscle reflex). The quality and duration of chlorpheniramine and bupivacaine on infiltrative cutaneous analgesia were compared. Results We revealed that subcutaneous chlorpheniramine, as well as the local anesthetic bupivacaine elicited cutaneous analgesia in a dosage-dependent manner. Based on their ED(50)s (50% effective doses), the relative potency was found to be chlorpheniramine [1.13 (1.05-1.22) mu mol] < bupivacaine [0.52 (0.46-0.58) mu mol] (p < 0.01). When comparing the ED(25)s, ED(50)s and ED(75)s, full recovery time induced by chlorpheniramine was longer (p < 0.01) than that induced by bupivacaine. Conclusions Our preclinical data demonstrated that both chlorpheniramine and bupivacaine dose-dependently provoked the cutaneous analgesic effects. Chlorpheniramine with a more prolonged duration was less potent than bupivacaine in inducing cutaneous analgesia.
    關聯: Pharmacological Reports, v.72, n.4, pp.827-832
    Appears in Collections:[藥學系(所)] 期刊論文

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