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    Title: Relationship between fasting plasma glucose and incidence of diabetes in children and adolescents
    Authors: Yang, C-Y
    Li, H-Y
    Sung, F-C
    Tan, E. Chia-Hui
    Jung-Nan Wei(魏榮男)
    Chuang, L-M
    Contributors: E Da Hosp, Dept Med Imaging
    I Shou Univ, Sch Med Int Student
    Natl Taiwan Univ Hosp, Dept Med Imaging
    Natl Taiwan Univ, Coll Med
    Natl Taiwan Univ Hosp, Dept Internal Med
    China Med Univ, Coll Publ Hlth, Inst Environm Hlth
    Minist Hlth & Welf, Natl Res Inst Chinese Med
    Natl Yang Ming Univ, Inst Hosp & Hlth Care Adm
    Chia Nan Univ Pharm & Sci
    Natl Taiwan Univ, Coll Med, Grad Inst Clin Med
    Keywords: RISK-FACTORS
    Date: 2019-05
    Issue Date: 2020-07-29 13:55:12 (UTC+8)
    Publisher: WILEY
    Abstract: Aim To investigate the appropriate fasting plasma glucose threshold by which to define prediabetes in children and adolescents, based on its ability to predict incident paediatric diabetes. Methods In a nationwide survey of diabetes and renal disease conducted between 1992 and 2000 in all school-aged children in Taiwan, those with abnormal results in repeated urine tests received further physical examination and blood tests. Students who had blood tests for at least two time points were selected for the present study (N = 12 119). The incidence of paediatric diabetes, adjusted hazard ratio and predictive power of fasting plasma glucose were analysed. Results The incidence of paediatric diabetes increased with increasing fasting plasma glucose levels. Groups with fasting plasma glucose >5.6 mmol/l had a higher adjusted hazard ratio. The adjusted hazard ratio of incident diabetes for participants with higher fasting plasma glucose rose continuously when using a higher threshold for fasting plasma glucose. The area under the receiver-operating characteristic curve for fasting plasma glucose was 0.628 for predicting paediatric diabetes. The association between fasting plasma glucose and incident paediatric diabetes and the area under the receiver-operating characteristic curve were similar in boys and girls and were higher in the age group 12-18 years. According to receiver-operating characteristic curve analysis, the optimal thresholds, sensitivity and specificity were 4.75 mmol/l, 65% and 51%, respectively, for those aged 6-11 years and 5.19 mmol/l, 60% and 73%, respectively, for those aged 12-18 years. Conclusion Fasting plasma glucose is associated with the incidence of paediatric diabetes. The results of the present study can be used as reference data to suggest a cut-off value to define paediatric prediabetes.
    Relation: Diabetic Medicine, v.36, n.5, pp. 633-643
    Appears in Collections:[Dept. of Occupational Safety] Periodical Articles

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