Chemical constituents from the stems of Machilus philippinensis Merr. and the neuroprotective activity of cinnamophilin

doi:10.1039/c9ra03514a

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Title:	Chemical constituents from the stems of Machilus philippinensis Merr. and the neuroprotective activity of cinnamophilin
Authors:	Tai, Shih-Huang Kuo, Ping-Chung Lam, Sio Hong Shiow-Chyn Huang(黃秀琴) Kuo, Yi-Zhuan Hung, Hsin-Yi Liou, Meei-Jen Shieh, Po-Chuen Lee, E. -Jian Wu, Tian-Shung
Contributors:	Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Surg Natl Cheng Kung Univ, Coll Med, Sch Pharm Chia Nan Univ Pharm & Sci, Dept Pharm Natl Cheng Kung Univ, Dept Chem Providence Univ, Dept Appl Chem Tajen Univ, Coll Pharm & Hlth Care, Dept Pharm
Keywords:	MESO-DIHYDROGUAIARETIC ACID FOCAL CEREBRAL-ISCHEMIA CYTOTOXIC NEOLIGNANS THUNBERGII PROTECT PRIMARY CULTURES LIGNANS DERIVATIVES BARK BUTANOLIDES METABOLITES
Date:	2019-07
Issue Date:	2020-07-29 13:54:58 (UTC+8)
Publisher:	ROYAL SOC CHEMISTRY
Abstract:	The Machilus genus (Lauraceae) had been extensively utilized in folk medicine due to its broad range of bioactivities. In the present study, a series of chromatographic separations of the methanol extract of stems of M. philippinensis led to the identification of thirty eight compounds totally. Among these, biscinnamophilin (1), machilupins A-C (2-4), machilutone A (5), and machilusoxide A (6) were new compounds reported for the first time. In addition, 5 was characterized with a unprecedented carbon skeleton. Other known compounds, including the major compounds cinnamophilin (7) and meso-dihydroguaiaretic acid (8), are identified by comparison of their physical and spectroscopic data with reported values. One of the reported compounds, cinnamophilin A (10), should be revised as dehydroguaiaretic acid (9) after careful comparison of all the H-1 and C-13 NMR data. Moreover, the neuroprotective activity of cinnamophilin (7) was examined in a primary cortical neuron culture and the results indicated that 7 was effective against glutamate induced excitotoxicity.
Relation:	Rsc Advances, v.9, n.38, pp.21616-21625
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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