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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32679


    標題: Chemical constituents from the stems of Machilus philippinensis Merr. and the neuroprotective activity of cinnamophilin
    作者: Tai, Shih-Huang
    Kuo, Ping-Chung
    Lam, Sio Hong
    Shiow-Chyn Huang(黃秀琴)
    Kuo, Yi-Zhuan
    Hung, Hsin-Yi
    Liou, Meei-Jen
    Shieh, Po-Chuen
    Lee, E. -Jian
    Wu, Tian-Shung
    貢獻者: Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Surg
    Natl Cheng Kung Univ, Coll Med, Sch Pharm
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Natl Cheng Kung Univ, Dept Chem
    Providence Univ, Dept Appl Chem
    Tajen Univ, Coll Pharm & Hlth Care, Dept Pharm
    關鍵字: MESO-DIHYDROGUAIARETIC ACID
    FOCAL CEREBRAL-ISCHEMIA
    CYTOTOXIC NEOLIGNANS
    THUNBERGII PROTECT
    PRIMARY CULTURES
    LIGNANS
    DERIVATIVES
    BARK
    BUTANOLIDES
    METABOLITES
    日期: 2019-07
    上傳時間: 2020-07-29 13:54:58 (UTC+8)
    出版者: ROYAL SOC CHEMISTRY
    摘要: The Machilus genus (Lauraceae) had been extensively utilized in folk medicine due to its broad range of bioactivities. In the present study, a series of chromatographic separations of the methanol extract of stems of M. philippinensis led to the identification of thirty eight compounds totally. Among these, biscinnamophilin (1), machilupins A-C (2-4), machilutone A (5), and machilusoxide A (6) were new compounds reported for the first time. In addition, 5 was characterized with a unprecedented carbon skeleton. Other known compounds, including the major compounds cinnamophilin (7) and meso-dihydroguaiaretic acid (8), are identified by comparison of their physical and spectroscopic data with reported values. One of the reported compounds, cinnamophilin A (10), should be revised as dehydroguaiaretic acid (9) after careful comparison of all the H-1 and C-13 NMR data. Moreover, the neuroprotective activity of cinnamophilin (7) was examined in a primary cortical neuron culture and the results indicated that 7 was effective against glutamate induced excitotoxicity.
    關聯: Rsc Advances, v.9, n.38, pp.21616-21625
    Appears in Collections:[藥學系(所)] 期刊論文

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