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| 標題: | Chemical constituents from the stems of Machilus philippinensis Merr. and the neuroprotective activity of cinnamophilin |
| 作者: | Tai, Shih-Huang
Kuo, Ping-Chung
Lam, Sio Hong
Shiow-Chyn Huang(黃秀琴)
Kuo, Yi-Zhuan
Hung, Hsin-Yi
Liou, Meei-Jen
Shieh, Po-Chuen
Lee, E. -Jian
Wu, Tian-Shung |
| 貢獻者: | Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Surg
Natl Cheng Kung Univ, Coll Med, Sch Pharm
Chia Nan Univ Pharm & Sci, Dept Pharm
Natl Cheng Kung Univ, Dept Chem
Providence Univ, Dept Appl Chem
Tajen Univ, Coll Pharm & Hlth Care, Dept Pharm |
| 關鍵字: | MESO-DIHYDROGUAIARETIC ACID
FOCAL CEREBRAL-ISCHEMIA
CYTOTOXIC NEOLIGNANS
THUNBERGII PROTECT
PRIMARY CULTURES
LIGNANS
DERIVATIVES
BARK
BUTANOLIDES
METABOLITES |
| 日期: | 2019-07 |
| 上傳時間: | 2020-07-29 13:54:58 (UTC+8) |
| 出版者: | ROYAL SOC CHEMISTRY |
| 摘要: | The Machilus genus (Lauraceae) had been extensively utilized in folk medicine due to its broad range of bioactivities. In the present study, a series of chromatographic separations of the methanol extract of stems of M. philippinensis led to the identification of thirty eight compounds totally. Among these, biscinnamophilin (1), machilupins A-C (2-4), machilutone A (5), and machilusoxide A (6) were new compounds reported for the first time. In addition, 5 was characterized with a unprecedented carbon skeleton. Other known compounds, including the major compounds cinnamophilin (7) and meso-dihydroguaiaretic acid (8), are identified by comparison of their physical and spectroscopic data with reported values. One of the reported compounds, cinnamophilin A (10), should be revised as dehydroguaiaretic acid (9) after careful comparison of all the H-1 and C-13 NMR data. Moreover, the neuroprotective activity of cinnamophilin (7) was examined in a primary cortical neuron culture and the results indicated that 7 was effective against glutamate induced excitotoxicity. |
| 關聯: | Rsc Advances, v.9, n.38, pp.21616-21625 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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