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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32675


    標題: Topically Applied Cross-Linked Hyaluronan Attenuates the Formation of Spinal Epidural Fibrosis in a Swine Model of Laminectomy
    作者: Lin, Cheng-Li
    Jou, I-Ming
    Wu, Cheng-Yi
    Kuo, Yuh-Ruey
    Yang, Shih-Chieh
    Lee, Jung-Shun
    Tu, Yuan-Kun
    Chen, Sung-Ching
    Yi-Hung Huang(黃儀鴻)
    貢獻者: Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Orthopaed Surg
    Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Res Ctr Clin Med,Skeleton Mat & Biocompatibl Core
    I Shou Univ, E Da Hosp, Dept Orthopaed
    ChiaYi Christian Hosp, Dept Orthopaed
    Natl Cheng Kung Univ Hosp, Dept Surg, Div Neurosurg
    Maxigen Biotech Inc
    Chia Nan Univ Pharm & Sci, Dept Sports Management
    關鍵字: MATRIX METALLOPROTEINASES
    EXPRESSION
    CD44
    ACID
    FIBROBLASTS
    MODULATORS
    MIGRATION
    CYTOKINES
    SURGERY
    SYSTEM
    日期: 2019-10
    上傳時間: 2020-07-29 13:54:49 (UTC+8)
    出版者: NATURE PUBLISHING GROUP
    摘要: Epidural fibrosis is an inevitable aspect of the postoperative healing process which is one of the causes of failed back surgery syndrome following spinal surgery. The aim of the present study was to examine the inhibitory effect of 1,4-butanediol diglycidyl ether-crosslinked hyaluronan (cHA) on spinal epidural fibrosis in a swine model. Epidural fibrosis was induced through conduction of hemi-laminotomy (L2 and L3) or laminectomy (L4 and L5), while Ll was assigned as the control group in six pigs. The cHA was applied to L3 and L5 surgical sites. MRI evaluation, histologic examination, expressions of matrix metalloproteinases (MMPs), and cytokines in scar tissue were assessed four months after surgery. cHA treatment significantly decreased the scar formation in both hemi-laminotomy and laminectomy sites. cHA also significantly increased MMP-3 and MMP-9 expression in scar tissue. Further, the epithelial-mesenchyma I transition -related factors (transforming growth factor-beta and vimentin) were suppressed and the anti-inflammatory cytokines (CD44 and interleukin-6) were increasingly expressed in cHA-treated sites. The current study demonstrated that cHA may attenuate spinal epidural fibrosis formation after laminectomy surgery by enhancing the expression of MMPs and anti-inflammatory pathways.
    關聯: Scientific Reports, v.9, 14613
    Appears in Collections:[運動管理系] 期刊論文

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