Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/32670
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    Title: Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM
    Authors: Yen, I-Weng
    Lee, Chien-Nan
    Lin, Ming-Wei
    Fan, Kang-Chih
    Jung-Nan Wei(魏榮男)
    Chen, Kuan-Yu
    Chen, Szu-Chi
    Tai, Yi-Yun
    Kuo, Chun-Heng
    Lin, Chia-Hung
    Hsu, Chih-Yao
    Chuang, Lee-Ming
    Lin, Shin-Yu
    Li, Hung-Yuan
    Contributors: Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch, Hsinchu, Taiwan
    Natl Taiwan Univ Hosp, Dept Obstet & Gynecol, Taipei, Taiwan
    Chia Nan Univ Pharm & Sci, Tainan, Taiwan
    Ansn Clin, Hsinchu, Taiwan
    Cardinal Tien Hosp, Dept Internal Med, New Taipei, Taiwan
    Fu Jen Catholic Univ Hosp, Dept Internal Med, New Taipei, Taiwan
    Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan
    Keywords: BODY-MASS INDEX
    INSULIN
    INFLAMMATION
    Date: 2019-12
    Issue Date: 2020-07-29 13:54:35 (UTC+8)
    Publisher: PUBLIC LIBRARY SCIENCE
    Abstract: Aim Overweight and obesity are important risk factors of gestational diabetes mellitus (GDM). Clustering of metabolic risk factors in early pregnancy may be a potential pathogenesis between the link of overweight/obesity and GDM. Since it remains unexplored, we investigated if overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM in this cohort study. Methods Total 527 women who visited National Taiwan University Hospital for prenatal care in between November 2013 to April 2018 were enrolled. Risk factors of GDM in the first prenatal visit (FPV) were recorded. Overweight/obesity was defined if body mass index.24 kg/m(2). GDM was diagnosed from the result of a 75g oral glucose tolerance test in 24-28 gestational weeks. Results Overweight/obesity was associated with clustering of metabolic risk factors of GDM, including high fasting plasma glucose, high HbA1c, insulin resistance, high plasma triglyceride and elevated blood pressure in FPV (p< 0.05). There was a positive relationship between the number of metabolic risk factors and the incidence of GDM (p < 0.05). The odds ratios of HbA1c and diastolic blood pressure were higher in overweight/obese women, compared with those in normal-weight women. Conclusions Overweight/obesity is associated with clustering of metabolic risk factors in early pregnancy, which is correlated with higher risk of GDM. Our findings suggest that metabolic risk factors during early pregnancy should be evaluated in overweight/obese women.
    Relation: Plos One, v.14, n.12, e0225978
    Appears in Collections:[Dept. of Occupational Safety] Periodical Articles

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