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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32635


    標題: Expression of prothymosin in lung cancer is associated with squamous cell carcinoma and smoking
    作者: Yu-Hsuan Kuo(郭雨萱)
    Shiau, Ai-Li
    Tung, Chao-Ling
    Su, Yu-Chu
    Li, Chien-Feng
    Su, Bing-Hua
    Tsao, Chao-Jung
    Wu, Chao-Liang
    Feng, Yin-Hsun
    Wu, Pensee
    貢獻者: Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol
    Chia Nan Univ, Coll Pharm & Sci
    Natl Cheng Kung Univ, Med Coll, Dept Microbiol & Immunol
    Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Med Coll, Dept Otolaryngol
    Chi Mei Med Ctr, Dept Pathol
    Natl Cheng Kung Univ, Med Coll, Dept Biochem & Mol Biol
    Chi Mei Med Ctr, Div Hematol & Oncol
    Chung Hwa Univ Med Technol, Dept Nursing
    Imperial Coll London, Inst Reprod & Dev Biol
    關鍵字: prothymosin
    lung cancer
    squamous cell carcinoma
    cigarettes
    日期: 2019-06
    上傳時間: 2020-07-29 13:53:07 (UTC+8)
    出版者: SPANDIDOS PUBL LTD
    摘要: Prothymosin (ProT) is a nuclear protein that serves a role in oncogenesis, by promoting proliferation and inhibiting apoptosis in various malignancies. The present study was designed to investigate ProT expression in resected human non-small cell lung cancer to define the clinicopathological associations of ProT-positive lung cancer. Immunohistochemical staining of ProT was performed using tumor sample slides from 149 patients with non-small cell lung cancer, who underwent surgical resection. Association between the expression of ProT and the following clinicopathological parameters was accessed: Age, sex, stage, lymph node involvement, pathological subtype, recurrence and cigarette smoking. A total of 85 tumors (57%) were classified as ProT-positive lung cancer by staining intensity and 73 tumors (49%) were regarded as ProT-positive by scoring index. The majority of patients with ProT-positive tumors were younger (P=0.05) and had squamous cell carcinoma (P<0.01) compared with older and adenocarcinoma. Positive expression of ProT by staining intensity was associated with a higher incidence rate of cancer recurrence (P=0.05) compared with negative ProT expression. ProT was also associated with cigarette smoking, particularly in the group with squamous cell carcinoma. Therefore, the present data suggested that ProT-positive non-small cell lung cancer was associated with younger patients, squamous cell carcinoma, cigarette smoking and a higher incidence recurrence rate, subsequently indicating a subtype consisting of patients with smoking-associated inferior outcomes.
    關聯: Oncology Letters, v.17, n.6, pp.5740-5746
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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