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    標題: Effect of Vasicinone against Paraquat-Induced MAPK/p53-Mediated Apoptosis via the IGF-1R/PI3K/AKT Pathway in a Parkinson's Disease-Associated SH-SY5Y Cell Model
    作者: Ju, Da-Tong
    Sivalingam, Kalaiselvi
    Kuo, Wei-Wen
    Ho, Tsung-Jung
    Chang, Ruey-Lin
    Li-Chin Chung(鍾麗琴)
    Day, Cecilia Hsuan
    Viswanadha, Vijaya Padma
    Liao, Po-Hsiang
    Huang, Chih-Yang
    貢獻者: Natl Def Med Ctr, Triserv Gen Hosp, Dept Neurol Surg
    China Med Univ, China Med Univ Hosp, Dept Med Res
    China Med Univ, Dept Biol Sci & Technol, Taichung 404, Taiwan
    Tzu Chi Univ, Buddhist Tzu Chi Med Fdn, Hualien Tzu Chi Hosp, Dept Chinese Med
    China Med Univ, Coll Chinese Med, Sch Postbaccalaureate Chinese Med
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    MeiHo Univ, Dept Nursing
    Bharathiar Univ, Dept Biotechnol
    Hualien Tzu Chi Hosp, Cardiovasc & Mitochondria Related Dis Res Ctr
    Tzu Chi Univ Sci & Technol, Buddhist Tzu Chi Med Fdn, Ctr Gen Educ
    China Med Univ & Hosp, Grad Inst Biomed
    Asia Univ, Dept Biotechnol
    關鍵字: parkinson's disease
    vasicinone
    paraquat
    apoptosis
    reactive oxygen species
    neuroprotection
    日期: 2019-07
    上傳時間: 2020-07-29 13:52:41 (UTC+8)
    出版者: MDPI
    摘要: Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. In this study, we explored the neuroprotective effect and underlying molecular mechanism of vasicinone against paraquat-induced cellular apoptosis in SH-SY5Y cells. Vasicinone reduced the paraquat-induced loss of cell viability, rescued terminal deoxynucleotide transferase-mediated dUTP nick end-labeling (TUNEL)-positive apoptotic nuclei, and suppressed generation of reactive oxygen species (ROS) in a dose-dependent manner. Western blotting analysis revealed that vasicinone increased the phosphorylation of IGF1R/PI3K/AKT cell survival signaling molecules and downregulated the paraquat-induced, mitogen-activated protein kinase (MAPK)/c-Jun N-terminal kinase (JNK)-mediated apoptotic pathways compared to that observed in cells not treated with vasicinone. This protection depended critically on the activation of IGF1R, and the silencing of IGF1R by siRNA completely abrogated the protective effect of vasicinone in SH-SY5Y cells. Our findings indicated that vasicinone is a potential candidate for the treatment of Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders.
    關聯: Nutrients, v.11, n.7, 1655
    Appears in Collections:[醫務管理系(所)] 期刊論文

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