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    標題: Pterostilbene inhibits lung squamous cell carcinoma growth in vitro and in vivo by inducing S phase arrest and apoptosis
    作者: Tan, Kok-Tong
    Chen, Ping-Wen
    Li, Shiming
    Ke, Te-Min
    Lin, Sheng-Hao
    Ching-Chieh Yang(楊清傑)
    貢獻者: Tungs Taichung Metro Harbor Hosp, Dept Surg
    Natl Chung Hsing Univ, Inst Biomed Sci
    Huanggang Normal Univ, Hubei Key Lab Econ Forest Germplasm Improvement &
    Chi Mei Med Ctr, Dept Radiat Oncol
    Changhua Christian Hosp, Div Chest Med, Dept Internal Med
    Natl Sun Yat Sen Univ, Inst Biomed Sci
    Chia Nan Univ Pharm & Sci, Dept Pharm
    關鍵字: lung squamous cell carcinoma
    pterostilbene
    cell cycle
    apoptosis
    日期: 2019-08
    上傳時間: 2020-07-29 13:52:05 (UTC+8)
    出版者: SPANDIDOS PUBL LTD
    摘要: Natural dietary components have become the subject of an increasing amount of interest due to the side effects of anticancer treatment. Pterostilbene, an analog of resveratrol, is primarily found in grapes, and has been suggested to exert antioxidant and anticancer effects in different tumor types. The present study aimed to investigate the antitumor effects and molecular mechanisms of pterostilbene in the human lung squamous cell carcinoma (SqCC) cell line, H520. The results of the present study indicate that pterostilbene significantly reduced cell viability and induced S phase arrest, and that treatment with pterostilbene was associated with the downregulation of cyclin A and cyclin E, as with the upregulation of p21 and p27 expression in H520 cells. In the apoptosis analysis, pterostilbene induced S phase accumulation and the activation of caspase-3, -8 and -9 in H520 cells, potentially through the activation of extrinsic and intrinsic apoptotic pathways. Additionally, the in vivo study demonstrated that pterostilbene effectively inhibited lung SqCC growth in a H520 xenograft model. Given the in vitro and in vivo antitumor effects of pterostilbene demonstrated in the present study, pterostilbene may serve a novel and effective therapeutic agent to for patients with SqCC.
    關聯: Oncology Letters, v.18, n.2, pp.1631-1640
    Appears in Collections:[藥學系(所)] 期刊論文

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