Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/32605
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    標題: The Relationship Between Occupational Exposure to Low-dose Ionizing Radiation and Changes in Thyroid Hormones in Hospital Workers
    作者: Wong, Yi-Sin
    Cheng, Ya-Yun
    Tain-Junn Cheng(鄭天浚)
    Huang, Chien-Cheng
    Yeh, Jun-Jun
    Guo, How-Ran
    貢獻者: Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Family Med
    Natl Cheng Kung Univ, Dept Environm & Occupat Hlth, Coll Med
    Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
    Chia Nan Univ Pharm & Sci, Inst Ind Safety & Disaster Prevent
    Chi Mei Med Ctr, Dept Neurol
    Chi Mei Med Ctr, Dept Occupat Med
    Chi Mei Med Ctr, Dept Management Med Records & Informat
    Chi Mei Med Ctr, Dept Emergency Med
    Southern Taiwan Univ Sci & Technol, Dept Child Care & Educ
    Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med
    關鍵字: Ionizing radiation
    Occupation
    Thyroid hormone
    Thyroid stimulating hormone
    Thyroxine
    Triiodothyronine
    日期: 2019-07
    上傳時間: 2020-07-29 13:51:47 (UTC+8)
    出版者: LIPPINCOTT WILLIAMS & WILKINS
    摘要: Background: The effects of ionized radiation on the thyroid have been extensively studied. However, most studies have focused on high-dose radiation received accidentally or through therapy, and few were on low-dose occupational exposure. Methods: Using a retrospective cohort study design, we collected health examination reports from employees who worked on jobs with occupational exposure to radiation at a hospital to evaluate possible changes in the serum thyroid hormones and determine whether there is a dose-response effect. After excluding those with diseases that may affect thyroid function and who were pregnant at any given examination during the study periods we followed the remaining 326 workers for 12 years and evaluated the associations between radiation exposure and changes in serum thyroid hormones using the generalized estimating equation for repeated measures. Data from an external comparison cohort were used to adjust for changes over time. Results: We observed declines in triiodothyronine (T3) and thyroxine (T4) over the study period, but not in thyroid-stimulating hormone (TSH). In addition, we found negative dose-response relationships between exposure duration and declines in the serum levels of T3 (a change of -0.037 ng/ml/year after adjusting for sex and age at the beginning of follow-up; 95% confidence interval [CI] = - 0.042, -0.032 ng/ml/year) and T4 (-0.115 mu g/dl/year; 95% CI = - 0.140, -0.091 mu g/dl/year). We also observed an increase in the TSH level (0.683 mu IU/ml/year; 95% CI = 0.151, 1.214 mu IU/ml/year) after the ninth year of follow-up. Conclusions: We concluded that despite low exposure doses, occupational exposure to ionizing radiation in healthcare workers still may be associated with the declines in the serum levels of T3 and T4.
    關聯: Epidemiology, v.30, pp.S32-S38
    显示于类别:[職業安全衛生系(含防災所)] 期刊論文

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