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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32589


    標題: Clinicopathologic and Prognostic Significance of Thymopoietin-alpha Overexpression in Gastric Cancer
    作者: Ding-Ping Sun(孫定平)
    Liew, Phui-Ly
    Lin, Chih-Chan
    Hung, Shih-Ting
    Chen, Tai-Chi
    Fang, Chia-Lang
    Kai-Yuan Lin(林凱元)
    貢獻者: Chi Mei Med Ctr, Dept Surg
    Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
    Taipei Med Univ, Shuang Ho Hosp, Dept Pathol
    Taipei Med Univ, Coll Med, Dept Pathol
    Chi Mei Med Ctr, Dept Med Res
    Taipei Med Univ, Wang Fang Hosp, Dept Pathol
    Chia Nan Univ Pharm & Sci, Dept Biotechnol
    關鍵字: gastric cancer
    TMPO-alpha
    prognosis
    日期: 2019
    上傳時間: 2020-07-29 13:51:06 (UTC+8)
    出版者: IVYSPRING INT PUBL
    摘要: As one of the deadliest and most common malignancies in the world, gastric cancer (GC) represents a serious health threat. Despite recent advances in the field, the prognosis of patients with metastatic GC remains poor. In this study, we aimed to investigate the clinical impact of the alpha subunit of the nuclear structural protein thymopoietin (TMPO-alpha) in GC. The expression of TMPO-alpha in seven gastric cell lines was detected by immunoblotting. The expression level of TMPO-alpha levels in gastric tissues collected from 145 GC patients was examined by immunohistochemistry. The correlations between TMPO-alpha expression level and clinicopathologic parameters, as well as the association of TMPO-alpha expression with overall survival, were assessed. Immunohistochemistry showed that the expression of TMPO-alpha was significantly higher in GC tissues and cells in comparison with non-tumor tissues and cells. Furthermore, the overexpression of TMPO-alpha in gastric tissues (56%) was positively associated with Lauren classification (P = 0.0159), nodal status (P = 0.0265), distant metastasis (P < 0.0001), stage (P = 0.0367), and degree of differentiation (P = 0.0009). Patients with high TMPO-alpha levels had a significantly poorer overall survival than those with low levels (P = 0.001). Multivariate Cox regression analysis also indicated that TMPO-alpha was an independent prognostic marker for GC (P = 0.045). In addition, studies conducted in GC cells indicated that knockdown of TMPO-alpha suppressed cell proliferation and invasion. These findings indicate that TMPO-alpha overexpression can predict clinicopathologic features and the outcome of patients with GC.
    關聯: Journal of Cancer, v.10, n.21, pp.5099-5107
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