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    標題: Protective effects of antioxidant egg-chalaza hydrolysates against chronic alcohol consumption-induced liver steatosis in mice
    作者: Yang, Kuo-Tai
    Lin, Yi-Ling
    Lin, Yu-Xuan
    Wang, Sheng-Yao
    Wu, Yi-Hsieng S.
    Chou, Chung-Hsi
    Shih-Guei Fu(傅世貴)
    Chen, Yi-Chen
    貢獻者: Natl Taiwan Univ, Dept Anim Sci & Technol, Taipei, Taiwan
    Natl Pingtung Univ Sci & Technol, Dept Anim Sci
    Natl Taiwan Univ, Sch Vet Med
    Natl Taiwan Univ, Zoonoses Res Ctr
    Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth
    關鍵字: alcoholic fatty liver
    amino acid profile
    in vitro and in vivo antioxidant effects
    lipid metabolism
    protease-A-digested crude chalaza hydrolysate
    日期: 2019-03
    上傳時間: 2020-07-29 13:47:34 (UTC+8)
    出版者: WILEY
    摘要: BACKGROUND Reactive oxygen species (ROS) overproduction is highly related to some human chronic diseases. There are approximately 400 metric tons of chalazae produced yearly after the processing of the liquid-egg production, which are disposed of as waste. The objectives of this study were to look for the optimal production condition of antioxidant crude chalaza hydrolysates and evaluate the in vivo antioxidant capacity via a chronic alcohol consumption mouse model. RESULTS Antioxidant crude chalaza hydrolysates (CCH-As) could be produced by protease A at 1:100 ratio (w/w) and 0.5 h hydrolytic period. After our analyses, CCH-As were rich in leucine, arginine, phenylalanine, valine, lysine and antioxidant dipeptides (anserine and carnosine), and the major molecular masses were lower than 15 kDa. Regarding protective effects of CCH-As against oxidative damage in alcoholic-liquid-diet-fed mice, alcohol-fed mice had lower (P < 0.05) liver antioxidant capacities, and higher (P < 0.05) liver lipid contents, serum lipid/liver damage indices and IL-1 beta/IL-6 values. CCH-A supplementation reversed (P < 0.05) liver antioxidant capacities and reduced (P < 0.05) serum/liver lipids in alcohol-fed mice, which may result from increased (P < 0.05) fecal lipid output, upregulated (P < 0.05) fatty acid beta-oxidation and downregulated (P < 0.05) lipogenesis in the liver. CONCLUSION Taken together, this CCH-A should benefit the liquid-egg industry, while also offering consumers a choice of healthy ingredients from animal sources. (c) 2018 Society of Chemical Industry
    關聯: Journal of the Science of Food and Agriculture, v.99, n.5, pp.2300-2310
    Appears in Collections:[生活應用與保健系] 期刊論文

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