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    標題: Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer
    作者: Wu, Pei-Yi
    Lin, Yueh-Chien
    Huang, Yuan-Li
    Chen, Wei-Min
    Chen, Chien-Chin
    Lee, Hsinyu
    貢獻者: Acad Sinica, Inst Cellular & Organism Biol
    Natl Taiwan Univ, Dept Life Sci
    Asia Univ, Dept Biotechnol
    China Med Univ, China Med Univ Hosp, Dept Med Res
    Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Pathol
    Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
    Natl Taiwan Univ, Dept Elect Engn
    Natl Taiwan Univ, Inst Biomed Elect & Bioinformat
    Natl Taiwan Univ, Ctr Biotechnol
    關鍵字: LPA
    LPA receptor
    prostate cancer
    VEGF-C
    lymphangiogenesis
    日期: 2018-11
    上傳時間: 2019-12-16 09:35:42 (UTC+8)
    出版者: MDPI
    摘要: Prostate cancer (PCa) is the most common noncutaneous cancer in men worldwide. One of its major treatments is androgen deprivation therapy, but PCa frequently relapses as aggressive castration resistant local tumors and distal metastases. Hence, the development of novel agents or treatment modalities for advanced PCa is crucial. Many tumors, including PCa, first metastasize to regional lymph nodes via lymphatic vessels. Recent findings demonstrate that the bioactive lipid lysophosphatidic acid (LPA) promotes PCa progression by regulating vascular endothelial growth factor-C (VEGF-C), a critical mediator of tumor lymphangiogenesis and lymphatic metastasis. Many of the underlying molecular mechanisms of the LPA-VEGF-C axis have been described, revealing potential biomarkers and therapeutic targets that may aid in the diagnosis and treatment of advanced PCa. Herein, we review the literature that illustrates a functional role for LPA signaling in PCa progression. These discoveries may be especially applicable to anti-lymphangiogenic strategies for the prevention and therapy of metastatic PCa.
    關聯: Molecular Carcinogenesis, v.10, n.11, 413
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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