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    標題: Regulatory Efficacy of Brown Seaweed Lessonia nigrescens Extract on the Gene Expression Profile and Intestinal Microflora in Type 2 Diabetic Mice
    作者: Zhao, Chao
    Yang, Chengfeng
    Chen, Mingjun
    Lv, Xucong
    Liu, Bin
    Yi, Lunzhao
    Cornara, Laura
    Wei, Ming-Chi
    Yang, Yu-Chiao
    Tundis, Rosa
    Xiao, Jianbo
    貢獻者: Fujian Agr & Forestry Univ, Coll Food Sci
    Univ Calif Davis, Dept Chem
    Quanzhou Normal Univ, Fujian Prov Key Lab Dev Bioact Mat Marine Algae
    Kunming Univ Sci & Technol, Yunnan Food Safety Res Inst
    Univ Genoa, Dipartimento Sci Terra Ambiente & Vita, Genoa
    Chia Nan Univ Pharm & Sci, Dept Appl Geoinformat
    Kaohsiung Med Univ, Dept & Grad Inst Pharmacol
    Univ Calabria, Dept Pharm Hlth & Nutr Sci, Arcavacata Di Rende
    Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Ave Univ
    關鍵字: anti-diabetic activity
    high-throughput 16S rRNA gene sequencing
    intestinal microflora
    Lessonia nigrescens
    signaling pathway
    日期: 2018-02
    上傳時間: 2019-11-15 15:48:58 (UTC+8)
    出版者: WILEY
    摘要: Scope: In this study, the antidiabetic activity of Lessonia nigrescens ethanolic extract (LNE) is investigated in streptozotocin (SZT)-induced type 2 diabetic mice fed with a high-sucrose/high-fat diet. Methods and results: Ultra high performance liquid chromatography coupled with photo-DAD and electospray ionization-mass spectrometry (ESI-MS) is employed to analyze the major compounds in LNE. The components of the intestinal microflora in type 2 diabetic mice are analyzed by high-throughput next-generation 16S rRNA gene sequencing. Fasting blood glucose levels in diabetic mice are significantly decreased after LNE administration. The histology reveals that LNE could protect the cellular architecture of liver and kidney. LNE treatment significantly increases Bacteroidetes and decreases Firmicutes populations in intestinal microflora. Specifically, It could selectively enrich the amounts of beneficial bacteria, Barnesiella, as well as reduce the abundances of Clostridium and Alistipes. The increased gene and protein expression levels of phosphatidylinositol 3-kinase (PI3K) in the liver are observed in LNE treatment groups, while the expressions of c-Jun N-terminal kinase (JNK) are significantly downregulated. Conclusion: The above findings suggest that LNE could be considered as a functional food for reducing blood glucose and regulating intestinal microflora.
    link: http://dx.doi.org/10.1002/mnfr.201700730
    關聯: Cancer Medicine, v.62, n.4, 1700730
    Appears in Collections:[應用空間資訊系(所)] 期刊論文

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