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    標題: Angiotensin 1-7 modulates electrophysiological characteristics and calcium homoeostasis in pulmonary veins cardiomyocytes via MAS/PI3K/eNOS signalling pathway
    作者: Lu, Yen-Yu
    Wu, Wen-Shiann
    Lin, Yung-Kuo
    Cheng, Chen-Chuan
    Chen, Yao-Chang
    Chen, Shih-Ann
    Chen, Yi-Jen
    貢獻者: Sijhih Cathay Gen Hosp, Div Cardiol, Dept Internal Med
    Fu Jen Catholic Univ, Sch Med
    Chi Mei Med Ctr, Dept Cardiol
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Taipei Med Univ, Div Cardiovasc Med, Dept Internal Med, Wan Fang Hosp
    Taipei Med Univ, Div Cardiol, Dept Internal Med, Sch Med,Coll Med
    Natl Def Med Ctr, Dept Biomed Engn
    Natl Yang Ming Univ, Sch Med, Div Cardiol
    Natl Yang Ming Univ, Vet Gen Hosp Taipei, Cardiovasc Res Ctr
    Taipei Med Univ, Grad Inst Clin Med, Coll Med
    關鍵字: angiotensin-(1-7)
    calcium homoeostasis
    electrophysiology
    pulmonary vein
    日期: 2018-01
    上傳時間: 2019-11-15 15:48:52 (UTC+8)
    出版者: WILEY
    摘要: BackgroundAtrial fibrillation (AF) is the most common sustained arrhythmia, and pulmonary veins (PVs) play a critical role in triggering AF. Angiotensin (Ang)-(1-7) regulates calcium (Ca2+) homoeostasis and also plays a critical role in cardiovascular pathophysiology. However, the role of Ang-(1-7) in PV arrhythmogenesis remains unclear. Materials and methodsConventional microelectrodes, whole-cell patch-clamp and the fluo-3 fluorimetric ratio technique were used to record ionic currents and intracellular Ca2+ in isolated rabbit PV preparations and in single isolated PV cardiomyocytes, before and after administration of Ang-(1-7). ResultsAng (1-7) concentration dependently (0.1, 1, 10 and 100 nmol/L) decreased PV spontaneous electrical activity. Ang-(1-7) (100 nmol/L) decreased the late sodium (Na+), L-type Ca2+ and Na+-Ca2+ exchanger currents, but did not affect the voltage-dependent Na+ current in PV cardiomyocytes. In addition, Ang-(1-7) decreased intracellular Ca2+ transient and sarcoplasmic reticulum Ca2+ content in PV cardiomyocytes. A779 (a Mas receptor blocker, 3 mol/L), L-NAME (a NO synthesis inhibitor, 100 mol/L) or wortmannin (a specific PI3K inhibitor, 10 nmol/L) attenuated the effects of Ang-(1-7) (100 nmol/L) on PV spontaneous electric activity. ConclusionAng-(1-7) regulates PV electrophysiological characteristics and Ca2+ homoeostasis via Mas/PI3K/eNOS signalling pathway.
    link: https://doi.org/10.1111/eci.12854
    Appears in Collections:[藥學系(所)] 期刊論文

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