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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32302


    標題: Adipose-derived stem cells decrease cardiomyocyte damage induced by porphyromonas gingivalis endotoxin through suppressing hypertrophy, apoptosis, fibrosis, and MAPK markers
    作者: Chen, Tung-Sheng
    Kuo, Chia-Hua
    Battsengel, Sarnai
    Pan, Lung-Fa
    Day, Cecilia Hsuan
    Shen, Chia-Yao
    Chung, Li-Chin
    Padma, V. Vijaya
    Yao, Chen-Kai
    Lin, Yueh-Min
    Huang, Chih-Yang
    貢獻者: Natl Taiwan Normal Univ, Sch Life Sci
    China Med Univ, Grad Inst Basic Med Sci
    Univ Taipei, Dept Sports Sci
    Intermed Hosp
    Armed Force Taichung Gen Hosp, Div Cardiol
    Univ Sci & Technol, Dept Med Imaging & Radiol Sci Cent Taiwan
    MeiHo Univ, Dept Nursing
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    Bharathiar Univ, Dept Biotechnol
    Washington High Sch
    Changhua Christian Hosp, Dept Pathol
    Jen Teh Jr Coll Med Nursing & Management
    China Med Univ, Grad Inst Chinese Med Sci
    Ton Duc Thang Univ, Fac Appl Sci, Tan Phong Ward
    China Med Univ, Grad Inst Chinese Med Sci
    Asia Univ, Dept Hlth & Nutr Biotechnol
    關鍵字: cardiomyopathy
    endotoxin
    IGF1
    periodontal disease
    stem cell
    日期: 2018-04
    上傳時間: 2019-11-15 15:48:46 (UTC+8)
    出版者: WILEY
    摘要: Heart failure is one of the complications related to periodontal disease. In addition to drugs or herbal medicines, stem cell therapy shows potential in the treatment of cardiomyopathy. This study investigates if stem cells exhibit beneficial effects on cardiomyocyte damage induced by porphyromonas gingivalis endotoxin (Pg-LPS). From the experimental results we find that Pg-LPS reduce cardiomyocyte viability via the activation of apoptosis, hypertrophy, fibrosis and MAPK signaling. Pg-LPS damaged cardiomyocytes co-cultured with adipose-derived stem cells (ADSC) increases cardiomyocyte viability through suppressing the pathological markers described above. Further evidence implies that survival marker, IGF1, secreted from ADSC, may play an important role in the Pg-LPS induced protective effect on cardiomyocyte damage.
    link: http://dx.doi.org/10.1002/tox.22536
    關聯: Scientific Reports, v.33, n.4, pp.508-513
    Appears in Collections:[醫務管理系(所)] 期刊論文

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