Isocapnic buffering phase: a useful indicator of exercise endurance in patients with coronary artery disease

doi:10.1080/00913847.2018.1426967

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Title:	Isocapnic buffering phase: a useful indicator of exercise endurance in patients with coronary artery disease
Authors:	Yen, Yun-Shan Su, Daniel Chiung Jui Yuan, Kuo-Shu Chen, Po-Wei Chow, Julie Chi Chou, Willy
Contributors:	Chi Mei Med Ctr, Dept Phys Med & Rehabil Natl Sun Yat Sen Univ, Dept Business Management Chi Mei Med Ctr, Dept Pediat Chia Nan Univ Pharm & Sci, Dept Recreat & Healthcare Management Chia Nan Univ Pharm & Sci, Inst Recreat Ind Management
Keywords:	Isocapnic buffering phase cardiopulmonary exercise test cardiopulmonary function endurance performance coronary artery disease
Date:	2018
Issue Date:	2019-11-15 15:48:24 (UTC+8)
Publisher:	TAYLOR & FRANCIS LTD
Abstract:	Objectives: The significance of the isocapnic buffering (IB) phase - the period between the first ventilatory threshold (1st VT) and respiratory compensation point (RCP) - has not been adequately established in patients. This study aimed to determine the clinical significance of the IB phase in patients with coronary artery disease (CAD). Methods: This retrospective study included data of sixty-two CAD patients after coronary artery bypass graft (CABG) or percutaneous coronary intervention (PCI) performed in a single medical center between 2010 - 2014. According to their physical conditions, the patients performed incremental cardiopulmonary exercise test (CPET) using a cycle ergometer by the ramp of 5-20 W/min. Correlations between the corrected IB phase duration and age, body mass index (BMI), left ventricular ejection fraction (LVEF), and CPET parameters were evaluated using Pearson correlation coefficients. Variables predicting peak oxygen consumption (VO2) were evaluated using multiple regression. Results: Peak VO2 (p < 0.001), VO2 at RCP (p < 0.001), Delta O-2/Delta WR slope (p < 0.001), maximal partial pressure of end tidal CO2 (PetCO(2)) (p = 0.0012), VE/VCO2 slope (p = 0.010), BMI (p = 0.012), and age (p = 0.017) were significantly correlated, whereas LVEF (p = 0.246) and VO2 at 1st VT (p = 0.179) were not significantly correlated with the corrected IB phase duration. In multiple regression analysis, the corrected IB phase duration, VO2 at 1st VT, and Delta O-2/Delta WR slope were significantly associated with peak VO2. Conclusion: The findings indicate that the IB phase duration is a useful indicator of peripheral cardiopulmonary function and endurance performance in CAD patients. These findings could assist the exercise prescription of cardiac rehabilitation for patients with CAD.
???metadata.dc.relation.uri???:	http://dx.doi.org/10.1080/00913847.2018.1426967
Relation:	Cancer Science, v.46, n.2, pp.228-232
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

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