Antioxidant and anti-inflammatory capacities of collagen peptides from milkfish (Chanos chanos) scales

doi:10.1007/s13197-018-3148-4

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Title:	Antioxidant and anti-inflammatory capacities of collagen peptides from milkfish (Chanos chanos) scales
Authors:	Chen, Yu-Pei Liang, Chia-Hua Wu, Hong-Tan Pang, Hai-Yue Chen, Chuan Wang, Guey-Horng Chan, Leong-Perng
Contributors:	Xiamen Med Coll, Res Ctr Nat Cosmeceut Engn Xiamen Med Coll, Coll Fuijan Prov, Applicat Tech Engn Ctr Nat Cosmeceut Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Chia Nan Univ Pharm & Sci, Inst Cosmet Sci Xiamen Med Coll, Dept Pharm Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Otolaryngol Head & Neck Surg
Keywords:	Milkfish Fish scale Collagen peptide Antioxidant Anti-inflammation
Date:	2018-06
Issue Date:	2019-11-15 15:48:12 (UTC+8)
Publisher:	SPRINGER INDIA
Abstract:	Milkfish (Chanos chanos), which is resistant to water quality changes is the fourth largest aquaculture commodity. Abandoned wastes of fish scale and bones aggravate environmental pollution. In this study, the effect of collagen peptides isolated from milkfish scales (MSCP) by pepsin-soluble collagen method on cell viability was investigated. The antioxidant, anti-inflammatory, and DNA-protective activities of MSCP were also evaluated. Results revealed that more than 95% of viable cells were retained in human keratinocytes after addition of 100 mg/mL MSCP. Measurement of DPPH center dot and ABTS center dot + radical scavenging activities and cellular reactive oxygen species revealed the high antioxidant activities of MSCP. MSCP demonstrated anti-inflammatory activities by reducing lipoxygenase activity and nitric oxide (NO center dot) radicals. Moreover, DNA electrophoresis assay indicated that MSCP treatment can directly protect against cyclobutane di-pyrimidine production and DNA single-strand breaks, which are harmful effects of UV radiation and H2O2. Given its antioxidant, anti-inflammatory, and DNA-protective activities, MSCP has potential applications in cosmeceuticals and supplementary health food.
???metadata.dc.relation.uri???:	http://dx.doi.org/10.1007/s13197-018-3148-4
Relation:	Acta Cardiologica Sinica, v.55, n.6, pp.2310-2317
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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