Exercise Rehabilitation Attenuates Cognitive Deficits in Rats with Traumatic Brain Injury by Stimulating the Cerebral HSP20/BDNF/TrkB Signalling Axis

doi:10.1007/s12035-018-1011-2

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Title:	Exercise Rehabilitation Attenuates Cognitive Deficits in Rats with Traumatic Brain Injury by Stimulating the Cerebral HSP20/BDNF/TrkB Signalling Axis
Authors:	Chou, Willy Liu, Yu-Fan Lin, Cheng-Hsien Lin, Mao-Tsun Chen, Chi-Chun Liu, Wen-Pin Chang, Ching-Ping Chio, Chung-Ching
Contributors:	Chi Mei Med Ctr, Dept Phys Med & Rehabil Chia Nan Univ Pharm & Sci, Dept Recreat & Healthcare Management Chi Mei Med Ctr, Dept Med Res Univ Tsukuba, Fac Hlth & Sport Sci Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management Natl Chin Yi Univ Technol, Dept Elect Engn Chi Mei Med Ctr, Dept Surg, Div Neurosurg
Keywords:	Physical exercise Traumatic brain injury Heat shock protein 20 Brain-derived neurotrophic factor
Date:	2018-11
Issue Date:	2019-11-15 15:48:06 (UTC+8)
Publisher:	SPRINGER
Abstract:	Physical exercise (PE) is an effective method for improving cognitive function among patients with traumatic brain injury (TBI). We previously demonstrated that PE with an infrared-sensing running wheel (ISRW) system provides strong neuroprotection in an experimental animal model of stroke. In this study, we used fluid percussion injury in rats to simulate mild TBI. For rats, we used both passive avoidance learning and the Y-maze tests to evaluate cognitive function. We investigated whether PE rehabilitation attenuated cognitive deficits in rats with TBI and determined the contribution of hippocampal and cortical expression of heat shock protein 20 (HSP20) to PE-mediated cognitive recovery. In addition to increasing hippocampal and cortical expression of HSP20, brain-derived neurotrophic factor (BDNF), and the tropomyosin receptor kinase B (TrkB) ratio, PE rehabilitation significantly attenuated brain contusion and improved cognitive deficits in the rat model. Furthermore, reducing hippocampal and cortical expression of HSP20 with an intracerebral injection of pSUPER hsp20 small interfering RNA significantly diminished the PE-induced overexpression of hippocampal and cortical BDNF and the TrkB ratio and also reversed the beneficial effect of PE in reducing neurotrauma and the cognitive deficits. A positive Pearson correlation was found between HSP20 and BDNF, as well as between HSP20 and TrkB, in the hippocampal and cortical tissues. We thus conclude that post-ischaemic ISRW exercise rehabilitation attenuates cognitive deficits, as well as brain contusions, in TBI rats by stimulating the cerebral HSP20/BDNF/TrkB signalling axis.
???metadata.dc.relation.uri???:	http://dx.doi.org/10.1007/s12035-018-1011-2
Relation:	Environmental Science and Pollution Research, v.55, n.11, pp.8602-8611
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

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