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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32267


    標題: Changing seroprevalence of hepatitis C virus infection among HIV-positive patients in Taiwan
    作者: Li, Chia-Wen
    Yang, Chia-Jui
    Sun, Hsin-Yun
    Tsai, Mao-Song
    Lin, Shih-Ping
    Lin, Te-Yu
    Cheng, Chien-Yu
    Lee, Yi-Chien
    Huang, Yu-Shan
    Liu, Chun-Eng
    Lee, Yuan-Ti
    Tang, Hung-Jen
    Wang, Ning-Chi
    Cheng, Shu-Hsing
    Ko, Wen-Chien
    Hung, Chien-Ching
    貢獻者: Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Internal Med
    Far Eastern Mem Hosp, Dept Internal Med
    Natl Yang Ming Univ, Sch Med
    Natl Taiwan Univ Hosp, Dept Internal Med
    Natl Taiwan Univ
    Catholic Fu Jen Med Coll, Dept Internal Med
    Taichung Vet Gen Hosp, Dept Internal Med
    Tri Serv Gen Hosp, Dept Internal Med
    Natl Def Med Ctr
    Taoyuan Gen Hosp, Minist Hlth & Welf, Dept Infect Dis
    Natl Yang Ming Univ, Sch Publ Hlth
    Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Internal Med
    Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch
    Changhua Christian Hosp, Dept Internal Med
    Chung Shan Med Univ, Sch Med
    Chung Shan Med Univ Hosp, Dept Internal Med
    Chi Mei Med Ctr, Dept Internal Med
    關鍵字: B-Virus
    Risk-Factors
    Viral-Hepatitis
    Epidemiology
    Men
    Sex
    Coinfection
    Prevalence
    Era
    日期: 2018-03-16
    上傳時間: 2019-11-15 15:47:28 (UTC+8)
    出版者: PUBLIC LIBRARY SCIENCE
    摘要: Objective The study aimed to describe the evolution of the seroprevalence of hepatitis C virus (HCV) among human immunodeficiency virus (HIV)-positive patients included in two cohorts in Taiwan. Methods We retrospectively collected the information on demographic and clinical characteristics of 4,025 and 3,856 HIV-positive Taiwanese, who were aged 18 years or older at designated hospitals around Taiwan in 2004 +/- 2007, when an outbreak of HIV infection was occurring, and 2012 +/- 2016, when the outbreak was controlled with the implementation of harm reduction program, respectively. Comparisons of HCV seropositivity were made among different age and risk groups for HIV transmission between these two cohorts. Results The overall HCV seroprevalence of the 2004-2007 cohort and 2012-2016 cohort was 43.4% (1,288/2,974) and 18.6% (707/3,793), respectively (P<0.001). The HCV seroprevalence among injecting drug users (IDUs), though decreasing, was constantly high across the two cohorts, 96.4% and 94.0% (P = 0.02), respectively, and all age groups. In contrast, the corresponding figures among men who have sex with men (MSM) and heterosexuals in the two cohorts were 5.9% vs. 3.5% (P = 0.002) and 9.4% vs. 10.9% (P = 0.59), respectively. Among sexually transmitted HIV-positive patients, HCV seropositivity was significantly correlated with age (adjusted odds ratio [aOR], per 1-year increase, 1.03; 95% confidence interval [CI], 1.02-1.05) and a rapid plasma reagin (RPR) titer >= 1: 8 (aOR, 1.58; 95% CI, 1.03-2.43) in a multivariate analysis including age, gender, route for HIV transmission, baseline CD4 count and plasma HIV RNA load, the presence of hepatitis B surface antigen, and an RPR titer >= 1: 8. Compared with heterosexuals, the aOR for HCV seropositivity among MSM was 0.47 (95% CI, 0.31-0.72). Conclusions HCV seroprevalence among HIV-positive patients in Taiwan decreased with time, probably related to the inclusion of younger adults and more non-IDUs, and remained high among IDUs. HCV seropositivity was associated with age and an RPR titer >= 1: 8 among patients who acquired HIV through sexual contact.
    link: http://dx.doi.org/10.1371/journal.pone.0194149
    關聯: Plos One, v.13, n.3, e0194149
    Appears in Collections:[保健營養系(所) ] 期刊論文

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