資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://ir.cnu.edu.tw/handle/310902800/32261
|
| 標題: | Less Severe but Prolonged Course of Acute Hepatitis A in Human Immunodeficiency Virus (HIV)-Infected Patients Compared With HIV-Uninfected Patients During an Outbreak: A Multicenter Observational Study |
| 作者: | Lee, Yu-Lin
Chen, Guan-Jhou
Chen, Nan-Yu
Liou, Bo-Huang
Wang, Ning-Chi
Lee, Yuan-Ti
Yang, Chia-Jui
Huang, Yu-Shan
Tang, Hung-Jen
Huang, Shie-Shian
Lin, Yi-Chun
Cheng, Chien-Yu
Lee, Chen-Hsiang
Chen, Tun-Chieh
Wu, Ting-Shu
Litt, Chun-Eng
Lu, Po-Liang
Hung, Chien-Ching |
| 貢獻者: | Changhua Christian Hosp, Dept Internal Med
Natl Taiwan Univ Hosp, Dept Internal Med
Natl Taiwan Univ, Coll Med
Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Internal Med
Hsinchu MacKay Mem Hosp, Dept Internal Med
Natl Def Med Ctr, Triserv Gen Hosp, Dept Internal Med
Chung Shan Med Univ, Sch Med
Chung Shan Med Univ Hosp, Dept Internal Med
Far Eastern Mem Hosp, Dept Internal Med
Natl Yang Ming Univ, Sch Med
Natl Taiwan Univ Hosp, Hsin Chu Branch, Dept Internal Med
Chi Mei Med Ctr, Dept Internal Med
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Keelung Chang Gung Mem Hosp, Dept Internal Med
Minist Hlth & Welf, Taoyuan Gen Hosp, Dept Internal Med
Natl Yang Ming Univ, Sch Publ Hlth |
| 關鍵字: | viral hepatitis
men who have sex with men
fecal-oral transmission
sexually transmitted disease
coagulopathy |
| 日期: | 2018-11-15 |
| 上傳時間: | 2019-11-15 15:47:15 (UTC+8) |
| 出版者: | OXFORD UNIV PRESS INC |
| 摘要: | Background. This multicenter retrospective cohort study aimed to compare the clinical presentations and evolution of acute hepatitis A (AHA) between human immunodeficiency virus (HIV)-infected patients and HIV-uninfected counterparts during the AHA outbreak. Methods. Clinical and laboratory data were collected from the medical records of the patients with AHA at the 14 hospitals around Taiwan between May 2015 and May 2017. Results. A total of 297 adult patients with AHA were included during the study period. Their mean age was 31.4 years (range, 19.0-76.1 years); 93.4% were men and 58.6% were men who have sex with men. Of 265 patients with known HIV serostatus, 166 (62.6%) were HIV infected. Compared with HIV-uninfected patients, HIV-infected patients had a lower peak alanine aminotransferase (ALT) level (median, 1312 vs 2014 IU/L, P = .003), less coagulopathy (6.0% vs 16.2%, P = .007), and less hepatomegaly or splenomegaly on imaging studies, but a higher rate of delayed resolution of hepatitis (38.8% vs 21.3%, P = .009). HIV-infected patients with plasma RNA load <1000 copies/ml, while receiving combination antiretroviral therapy (cART) had a higher peak ALT level (median, 1420 vs 978 IU/L P = .006) and less delay in resolution of hepatitis (30.6% vs 48.8%, P = .047) than patients without cART or with plasma RNA load >= 1000 copies/mL. Conclusions. During an AHA outbreak, HIV-infected patients had a lower severity, but delayed resolution, of AHA than HIV-uninfected patients. Better viral suppression by cART alleviated the impact of HIV infection on the disease course of AHA in HIV-infected patients. |
| link: | http://dx.doi.org/10.1093/cid/ciy328 |
| 關聯: | Computers & Education, v.67, n.10, pp.1595-1602 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| 10.1093-cid-ciy328.pdf | | 611Kb | Adobe PDF | 563 | 檢視/開啟 | | index.html | | 0Kb | HTML | 1767 | 檢視/開啟 |
|
在CNU IR中所有的資料項目都受到原著作權保護.
|
