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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32258


    標題: Reversible glycosidic switch for secure delivery of molecular nanocargos
    作者: Burnouf, Pierre-Alain
    Leu, Yu-Lin
    Su, Yu-Cheng
    Wu, Kenneth
    Lin, Wei-Chi
    Roffler, Steve R.
    貢獻者: Natl Yang Ming Univ, Taiwan Int Grad Program Mol Med
    Acad Sinica
    Acad Sinica, Inst Biomed Sci
    Natl Yang Ming Univ, Inst Biochem & Mol Biol
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Kaohsiung Med Univ, Coll Med, Grad Inst Med
    關鍵字: Liposomal Drug-Delivery
    Cells-In-Vitro
    Cancer-Therapy
    Lipophilic Drugs
    Topoisomerase-I
    Accumulation
    Camptothecin
    Efficacy
    Glucuronide
    Prodrug
    日期: 2018-05-10
    上傳時間: 2019-11-15 15:47:08 (UTC+8)
    出版者: NATURE PUBLISHING GROUP
    摘要: Therapeutic drugs can leak from nanocarriers before reaching their cellular targets. Here we describe the concept of a chemical switch which responds to environmental conditions to alternate between a lipid-soluble state for efficient cargo loading and a water-soluble state for stable retention of cargos inside liposomes. A cue-responsive trigger allows release of the molecular cargo at specific cellular sites. We demonstrate the utility of a specific glycosidic switch for encapsulation of potent anticancer drugs and fluorescent compounds. Stable retention of drugs in liposomes allowed generation of high tumor/blood ratios of parental drug in tumors after enzymatic hydrolysis of the glycosidic switch in the lysosomes of cancer cells. Glycosidic switch liposomes could cure mice bearing human breast cancer tumors without significant weight loss. The chemical switch represents a general method to load and retain cargos inside liposomes, thereby offering new perspectives in engineering safe and effective liposomes for therapy and imaging.
    關聯: Qjm-An International Journal of Medicine, v.9, 1843
    Appears in Collections:[藥學系(所)] 期刊論文

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