Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/32248
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18034/20233 (89%)
Visitors : 23350475      Online Users : 509
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/32248


    Title: Sequential Biotransformation of Antcin K by Bacillus subtilis ATCC 6633
    Authors: Chang, Te-Sheng
    Chiang, Chien-Min
    Siao, Yi-Yun
    Wu, Jiumn-Yih
    Contributors: Natl Univ Tainan, Dept Biol Sci & Technol
    Chia Nan Univ Pharm & Sci, Dept Biotechnol
    Natl Quemoy Univ, Dept Food Sci
    Keywords: Antrodia cinnamomea
    antcin K
    Bacillus subtilis
    biotransformation
    glycosylation
    Date: 2018-09
    Issue Date: 2019-11-15 15:46:44 (UTC+8)
    Publisher: MDPI
    Abstract: The biotransformation of antcin K, a major ergostane triterpenoid from the fruiting bodies of Antrodia cinnamomea, by Bacillus subtilis (B. subtilis) ATCC 6633 was studied. Four metabolites from the biotransformation were isolated with preparative high-performance liquid chromatography and identified as 25S-antcin K 26-O-beta-glucoside, 25R-antcin K 26-O-beta-glucoside, 25S-antcin K 26-O-beta-(6'-O-succinyl)-glucoside, and 25R-antcin K 26-O-beta-(6'-O-succinyl)-glucoside with mass and nuclear magnetic resonance spectral analysis. By using either 25S-antcin K 26-O-beta-glucoside or 25R-antcin K 26-O-beta-glucoside as the biotransformation precursor, it was proven that 25S-antcin K 26-O-beta-(6'-O-succinyl)-glucoside and 25R-antcin K 26-O-beta-(6'-O-succinyl)-glucoside were biotransformed from 25S-antcin K 26-O-beta-glucoside and 25R-antcin K 26-O-beta-glucoside, respectively. To the best of our knowledge, this is the first study on the glycosylation of triterpenoids from A. cinnamomea, and the first time the succinylation of triterpenoid glycosides by microorganisms has been found. In addition, all four antcin K glucoside derivatives are new compounds.
    ???metadata.dc.relation.uri???: http://dx.doi.org/10.3390/catal8090349
    Relation: Catalysts, v.8, n.9, 349
    Appears in Collections:[Dept. of Biotechnology (including master's program)] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    10.3390-catal8090349.pdf3053KbAdobe PDF441View/Open
    index.html0KbHTML941View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback