Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/32243
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 17333/19639 (88%)
造訪人次 : 5442198      線上人數 : 453
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://ir.cnu.edu.tw/handle/310902800/32243


    標題: Pterostilbene Attenuates Hexavalent Chromium-Induced Allergic Contact Dermatitis by Preventing Cell Apoptosis and Inhibiting IL-1 beta-Related NLRP3 Inflammasome Activation
    作者: Wang, Bour-Jr
    Chiu, Hui-Wen
    Lee, Yong-Lin
    Li, Chia-Yi
    Wang, Ying-Jan
    Lee, Yu-Hsuan
    貢獻者: Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
    Chia Nan Univ Pharm & Sci, Inst Cosmet Sci
    Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med
    Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Nephrol
    Taipei Med Univ, Coll Med, Grad Inst Clin Med
    Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth
    Univ Alberta, Honors Neurosci Neurosci & Mental Hlth Inst, Fac Sci
    China Med Univ, China Med Univ Hosp, Dept Med Res
    Natl Cheng Kung Univ, Coll Med, Dept Food Safety Hyg & Risk Management
    關鍵字: hexavalent chromium
    pterostilbene
    endoplasmic reticulum stress
    inflammatory cytokines
    NLRP3 inflammasome
    allergic contact dermatitis
    日期: 2018-12
    上傳時間: 2019-11-15 15:46:33 (UTC+8)
    出版者: MDPI
    摘要: Hexavalent chromium (Cr(VI)) is widely used in many industries but can induce contact dermatitis especially in cement industries. Many cement workers suffer from Cr(VI)-induced allergic contact dermatitis (ACD), and prevention and therapeutic strategies are still lacking. Pterostilbene (PT) is a natural compound predominantly found in blueberries. Studies indicate the potential use of PT as an effective anti-oxidative and anti-inflammatory agent. Herein, we investigated the possible mechanisms involved and whether chromium-induced ACD could be effectively inhibited by treating PT. In our in vivo study, epidermal Cr(VI) administration causes cutaneous inflammation in mice ear skin, and the pro-inflammatory cytokines, TNF-alpha, and IL-1 beta, were found in the epidermis, presenting the level of increase after Cr(VI) treatment. Meanwhile, the results of our in vitro experiment showed that apoptosis and endoplasmic reticulum (ER) stress were induced after treatment with different concentrations of Cr(VI) in HaCaT cells (human keratinocyte). Cr(VI) also induced TNF-alpha and IL-beta mRNA expressions, through the activation of the p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein kinase 2 (MK2) pathway. Notably, the severity of the skin reactions in the epicutaneous elicitation test significantly diminished when the mouse was treated with PT. Likewise, PT intervention also ameliorated the inflammation and apoptosis of HaCaT cells in vitro. Furthermore, our current findings demonstrated that the NLRP3 inflammasome could be involved in the Cr(VI)-mediated inflammation and apoptosis of ACD. Thus, interrupting this mechanism with proper nontoxic agents, such as PT, could be a new option to improve occupational chromium toxicity and hypersensitivity.
    link: http://dx.doi.org/10.3390/jcm7120489
    關聯: Bmc Pregnancy and Childbirth, v.7, n.12, 489
    顯示於類別:[化妝品應用與管理系(所)] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    10.3390-jcm7120489.pdf4074KbAdobe PDF36檢視/開啟
    index.html0KbHTML154檢視/開啟


    在CNU IR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋