資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://ir.cnu.edu.tw/handle/310902800/32219
|
| 標題: | Risk of Urinary Tract Carcinoma among Subjects with Bladder Pain Syndrome/Interstitial Cystitis: A Nationwide Population-Based Study |
| 作者: | Wu, Ming Ping
Luo, Hao Lun
Weng, Shih Feng
Ho, Chung-Han
Chancellor, Michael B.
Chuang, Yao Chi |
| 貢獻者: | Chi Mei Med Ctr, Div Urogynecol & Pelv Floor Reconstruct, Dept Obstet & Gynecol
Chia Nan Univ Pharm & Sci, Ctr Gen Educ
Fu Jen Catholic Univ, Coll Med, Dept Obstet & Gynecol
Chang Gung Univ, Coll Med, Kaohsiung Chang Gung Mem Hosp, Dept Urol
Chi Mei Med Ctr, Dept Med Res
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
William Beaumont Hosp, Dept Urol |
| 關鍵字: | Urothelial Carcinoma
Taiwan
Inflammation |
| 日期: | 2018 |
| 上傳時間: | 2019-11-15 15:45:38 (UTC+8) |
| 出版者: | HINDAWI LTD |
| 摘要: | Objective. To investigate the subsequent risks of urinary tract cancers among individuals with bladder pain syndrome/interstitial cystitis (BPS/IC), and gender differences, as well as the effect of associated comorbidity using a population-based administrative database in Taiwan. Patients and Methods. BPS/IC subjects (10192) and their age- and sex-matched non-BPS/IC control subjects (30576), who had no previous upper urinary tract cancer (UUC), bladder cancer (BC), and prostate cancer (PC), subsequently developed these disorders from the recruited date between 2002 and 2008 and the end of follow-up 2011. A Cox proportional hazards regression model was constructed to estimate the risk of subsequent UUC, BC, and PC following a diagnosis of IC/BPS. The effect of associated comorbidities was measured by Charlson Comorbidity Index (CCI). The risk of outcomes was assessed with Kaplan-Meier curves. Results. In the BPS/IC subjects, 37 (0.36%) received a diagnosis of BC, and 22 (0.22%) received a diagnosis of UUC; both were significantly higher than the control group, 19 (0.06%) for BC and 30 (0.10%) for UUC. Cox proportional analysis revealed that the adjusted HR for BC and UUC during the follow-up period for patients with IC/BPS was 5.44 (95% CI: 3.10-9.54) and 1.97(95% CI: 1.13-3.45) than that of comparison subjects. The HRs went up to 5.66(95% CI: 3.21-9.99) and 2.01 (95% CI: 1.143.55) after adjusted by Comorbidity Index (CCI). The male BPS/IC patients have a higher adjusted HR for BC; however, female patients have a higher adjusted HR for both BC and UUC. The adjusted HR for PC has no difference between BPS/IC and control group. Conclusion. Patients with BPS/IC are at risk of developing BC in both males and females, and UUC in females. This result reminds physicians to evaluate the potential risk of subsequent development of BC and UUC among individuals with BPS/IC. |
| 關聯: | Behavioural Neurology, v.2018, ID 7495081 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| 10.1155-2018-7495081.pdf | | 1937Kb | Adobe PDF | 282 | 檢視/開啟 | | index.html | | 0Kb | HTML | 1359 | 檢視/開啟 |
|
在CNU IR中所有的資料項目都受到原著作權保護.
|
