Long-term mortality of acetaminophen poisoning: a nationwide population-based cohort study with 10-year follow-up in Taiwan

doi:10.1186/s13049-017-0468-8

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Title:	Long-term mortality of acetaminophen poisoning: a nationwide population-based cohort study with 10-year follow-up in Taiwan
Authors:	Huang, Hung-Sheng Ho, Chung-Han Weng, Shih-Feng Hsu, Chien-Chin Wang, Jhi-Joung Su, Shih-Bin Lin, Hung-Jung Huang, Chien-Cheng
Contributors:	Chi Mei Med Ctr, Dept Emergency Med Chi Mei Med Ctr, Dept Occupat Med Chi Mei Med Ctr, Dept Med Res Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Kaohsiung Med Univ, Dept Healthcare Adm & Med Informat Southern Taiwan Univ Sci & Technol, Dept Biotechnol Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management Chi Mei Med Ctr, Dept Med Res Taipei Med Univ, Dept Emergency Med Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth Southern Taiwan Univ Sci & Technol, Bachelor Program Senior Serv Chi Mei Med Ctr, Dept Geriatr & Gerontol
Keywords:	Acetaminophen Long-term Mortality Poisoning
Date:	2018-01-08
Issue Date:	2019-11-15 15:43:20 (UTC+8)
Publisher:	BIOMED CENTRAL LTD
Abstract:	Background: The long-term mortality of acetaminophen (APAP) poisoning has not yet been well studied; hence, we conducted this study to gain understanding of this issue. Methods: We conducted a nationwide population-based cohort study by identifying 3235 participants with APAP poisoning and 9705 participants without APAP poisoning in Taiwan between 2003 and 2012 in the Nationwide Poisoning Database and Longitudinal Health Insurance Database 2000. Participants with APAP poisoning and control subjects were compared for the risk of all-cause mortality by follow-up until 2013. Results: Two hundred forty-one participants with APAP poisoning (7.5%) and ninety-four control subjects (1.0%) died during the follow-up. Participants with APAP poisoning had a higher risk of all-cause mortality than the control subjects (incidence rate ratio [IRR], 8.1; 95% confidence interval [CI], 6.3-10.2), especially in the subgroup aged 20 years and younger (IRR, 27.3; 95% CI, 3.5-215.5) and in the first 12 months after poisoning (IRR, 16.0; 95% CI, 9.9-25.7). The increased risk of all-cause mortality was found even up to 2 years after the index poisoning. Conclusion: APAP poisoning was associated with increased long-term mortality. Early referral for intensive aftercare and associated interventions are suggested; however, further studies of the method are needed for clarification.
???metadata.dc.relation.uri???:	http://dx.doi.org/10.1186/s13049-017-0468-8
Relation:	Journal of Experimental & Clinical Cancer Research, v.26, 5
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

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