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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32153


    標題: Treatment of beta-thujaplicin counteracts di(2-ethylhexyl)phthalate (DEHP)-exposed vascular smooth muscle activation, inflammation and atherosclerosis progression
    作者: Shih, Mei Fen
    Pan, Kuang-Hung
    Liu, Chia-Chyuan
    Shen, Chia-Rui
    Cherng, Jong Yuh
    貢獻者: Chia Nan Univ Pharm & Sci, Dept Pharm
    Natl Chung Cheng Univ, Dept Chem & Biochem
    Chia Nan Univ Pharm & Sci, Dept & Inst Cosmet Sci
    Chang Gung Univ, Dept Med Biotechnol & Lab Sci
    關鍵字: 13-thujaplicin
    DEHP
    Plasticizer
    E-selectin
    ICAM-1
    VCAM-1
    MMP-2
    MMP-9
    日期: 2018-02
    上傳時間: 2019-11-15 15:42:58 (UTC+8)
    出版者: ACADEMIC PRESS INC ELSEVIER SCIENCE
    摘要: The initiation of atherosclerosis involves up-regulation of molecules such as E-selectin, VCAM-1, and ICAM-1. The progression of atherosclerosis is linked to proliferation and migration of vascular smooth muscle cell via MMP-2 and MMP-9 activities. However, the etiology of atherosclerosis concerning plasticizers is unknown. We evaluated beta-thujaplicin in preventing the development of atherosclerosis in a model induced by pro-inflammatory cytokines. Moreover, we established a new atherosclerosis model in vascular smooth muscle cells (VSMC) exposed to a common contact plasticizer, di(2-ethylhexyl)phthalate (DEHP). SEVC4-10 endothelial cells were treated with 50% RAW conditioned medium and A7r5 VSMC was treated with the plasticizer, with/without beta-thujaplicin (4 or 12 mu M). Production of E-selectin, ICAM-1, and VCAM-1 in SEVC4-10 cells as well as MMP-2/MMP-9 (both expression and activity) in VSMC were monitored. Results showed that the conditioned medium induced E-selectin and ICAM were significantly prevented by beta-thujaplicin. However, inhibition on the production of VCAM by beta-thujaplicin was only seen in a concentration of 12 mu M. Both concentrations of beta-thujaplicin also significantly prevented DEHP-induced MMP-2 and MMP-9 expression and activities. Evidence uncovers that beta-thujaplicin has additional factors in amelioration of atherosclerosis and corroborates that beta-thujaplicin is a strong candidate in preventing the initiation and progression of atherosclerosis.
    link: http://dx.doi.org/10.1016/j.yrtph.2017.12.021
    關聯: Journal of Environmental Management, v.92, pp.333-337
    Appears in Collections:[藥學系(所)] 期刊論文
    [化妝品應用與管理系(所)] 期刊論文

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