裝載枸杞萃取物滴丸的製備與物化性質

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Title:	裝載枸杞萃取物滴丸的製備與物化性質 The Preparation and Physicochemical Properties of Goji Berry Extract-loaded Dripping Pills
Authors:	莊閔盛
Contributors:	藥學系林恆弘
Keywords:	枸杞 Goji
Date:	2018
Issue Date:	2019-02-27 16:50:02 (UTC+8)
Abstract:	枸杞是一種傳統中藥藥材，常用於眼睛保健的紅色果實。研究以來對枸杞中的營養價值一直很有興趣。其中有很多生物活性高的營養物質，如多醣複合物，類胡蘿蔔素，苯丙氨酸等多具抗氧化功能。在所有的增溶方法中，滴丸是一種提高藥物溶解速度和提高口服生物利用度的方法。滴丸的特點是製作設備簡單易操作、製造成本較低、攜帶方便和高生物可用度。與油性滴丸不同，配方中不含聚乙二醇的水性滴丸有可能改善對胃腸產生不適的問題。透過將中藥粹取物與藻酸及明膠混合，我們選擇配方9，將混合物滴入與溶液不互溶的液體中來製備滴丸。並採用紫外光分光光度法（UV spectrophotometry）含量分析，得到我們的枸杞滴丸有57.5％的回收率。進行差示掃描量熱法（DSC），除了水分以外無發現與賦形劑有交互作的情況，另外，使用物性測定儀測定後，發現我們的枸杞滴丸在15鐘內快速吸水膨脹，且在水中安定性高，達到載體運送的功能，保存效果相當好，安定性試驗後均有90%以上的含量，使枸杞這種高抗氧化的藥材不易變質變色，維持賣相。 Goji berry is a red berries. Traditional Chinese medicine commonly used to eye care. Their interest has increased in Goji berry for their supposed nutrient value. There are many nutrients with high biological activity. Among all the solubilization methods, dropping pill is a method to increase the rate of dissolution and improve the oral bioavailability of the drug. The feature of dripping pills are making simple device and easy to operate, dripping pill is the exact dose, quality and bioavailability. Different from Oily drop pills, the water-based dripping pills by the formulation consisted without Polyethylene glycol are possible improve gastrointestinal problems. Dripping pills were prepared by mixing the herbal extract with the alginic acid dropping the mixture into a liquid in which the droplets were insoluble. The objective of our study was to design and prepare the Goji berry extract-loaded dripping pills using alginic acid and gelatin as carriers by choose formula 9. The physicochemical properties of dripping pills were studies by differential scanning calorimetry (DSC) to know there are no interaction with excipients, Ultraviolet spectroscopy to confirm the recovery rate of the drug in dripping pills is 57.5%. It is found that our dripping pills are swelled by water absorption, release the drug in an infiltration manner, And have high stability in water and achieve the function of carrier transportation. Then the preservation effect is quite good. The content is more than 90% after the stability test, so that the medicinal material with high anti-oxidation is not easy to spoilage or change color and maintain selling phase.
Relation:	電子全文公開日期：2021-07-30，學年度：106， 47頁
Appears in Collections:	[Dept. of Pharmacy] Dissertations and Theses

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