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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31800


    標題: Increased Risk of Anxiety or Depression After Traumatic Spinal Cord Injury in Patients with Preexisting Hyperlipidemia: A Population-Based Study
    作者: Lim, Sher-Wei
    Nyam, Tee-Tau Eric
    Ho, Chung-Han
    Shiue, Yow-Ling
    Wang, Jhi-Joung
    Chio, Chung-Ching
    Kuo, Jinn-Rung
    貢獻者: Natl Sun Yat Sen Univ, Inst Biomed Sci
    Chi Mei Med Ctr, Dept Neurosurg
    Chi Mei Med Ctr, Dept Med Res
    Southern Taiwan Univ Sci & Technol, Dept Biotechnol
    Min Hwei Coll Hlth Care Management, Dept Nursing
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    關鍵字: Anxiety
    Depression
    Hyperlipidemia
    Population database
    Spinal cord injury
    日期: 2017-10
    上傳時間: 2018-11-30 15:57:15 (UTC+8)
    出版者: Elsevier Science Inc
    摘要: OBJECTIVE: Anxiety or depression (AD) is a common complication after traumatic spinal cord injury (tSCI). This study sought to investigate the role of preexisting hyperlipidemia in new-onset AD after tSCI using a longitudinal population database. METHODS: This retrospective cohort study used Longitudinal Health Insurance Database data from January 1997 to December 2011. The case and comparison groups were individuals who experienced tSCI and who did and did not have preexisting hyperlipidemia, respectively. Kaplan-Meier curves were plotted, and log-rank test was used to compare the differences between these 2 groups. A Cox regression model was used to estimate the relative risk of AD. RESULTS: A total of 26,892 adult patients were enrolled in this study. After 1: 3 matching with age and gender, it showed 1) tSCI patients with preexisting hyperlipidemia have a 1.32-fold adjusted hazard ratio (HR) compared with those without hyperlipidemia (P < 0.05); 2) The Kaplan-Meier plot in tSCI patients with hyperlipidemia were more likely to develop the new-onset AD than those without hyperlipidemia during the follow-up period (P = 0.0003); and 3) the stratified analysis showed the risk of AD among patients with tSCI aged 18-34 years (HR, 3.2; 95% confidence interval (CI) 1.2-8.9), male patients (HR, 1.3; 95% CI 1.1-1.6), and higher Charlson's comorbidity index (CCI) score (CCI > 2; HR, 1.9; 95% CI 1.2-2.9), and those with a history of stroke (HR, 1.7; 95% CI 1.0-2.7). CONCLUSIONS: Preexisting hyperlipidemia is an independent predictor of new-onset AD in patients with tSCI, especially in those who are younger, male, have a higher CCI score, and have stroke.
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