Sleep apnea is associated with an increased risk of mood disorders: a population-based cohort study

doi:10.1007/s11325-016-1389-x

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Title:	Sleep apnea is associated with an increased risk of mood disorders: a population-based cohort study
Authors:	Lu, Ming-Kun Tan, Hung-Pin Tsai, I-Ning Huang, Li-Chung Liao, Xin-Ming Lin, Sheng-Hsiang
Contributors:	Jianan Mental Hosp, Dept Hlth Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth Kaohsiung Vet Gen Hosp, Dept Psychiat Chung Hwa Univ Med Technol, Dept Acupressure Technol Natl Cheng Kung Univ, Dept Environm & Occupat Hlth, Coll Med Natl Cheng Kung Univ, Inst Clin Med, Coll Med Chia Nan Univ Pharm & Sci Taichung Vet Gen Hosp, Chia Yi Branch, Dept Psychiat Natl Cheng Kung Univ Hosp, Div Pulm Med, Dept Internal Med Natl Cheng Kung Univ Hosp, Biostat Consulting Ctr
Keywords:	Sleep apnea Mood disorder Nationwide population-based study Major depressive disorder Bipolar disorder
Date:	2017-05
Issue Date:	2018-11-30 15:56:53 (UTC+8)
Publisher:	Springer Heidelberg
Abstract:	The symptoms of sleep apnea, such as sleep fragmentation and oxygen desaturation, might be risk factors for subsequent mood disorder (MD), but associations between sleep apnea and MD remain unclear. This nationwide population-based study thus aimed to identify the risk of MD in patients with vs. without sleep apnea. This cohort study used data from the National Health Insurance database. In total, 5415 patients diagnosed with sleep apnea between 2000 and 2010 were evaluated, and 27,075 matched non-sleep apnea enrollees were included as a comparison cohort. All subjects were followed until 2011. The Cox proportional hazard ratio (HR) was used to investigate the relationship between MD and sleep apnea while controlling covariates and comorbidities of sleep apnea. Of 5415, 154 patients with sleep apnea (2.84 %) were diagnosed with MD during the follow-up period in comparison with 306 of 27,075 individuals (1.13 %) without antecedent sleep apnea. After adjusting for the selected factors and comorbidities, we found that patients with sleep apnea were from 1.82- to 2.07-fold greater risk of MD than the comparisons. Of the three subcategories of MD (major depressive disorder, bipolar disorder, and unspecified MD), sleep apnea had the highest predisposing risk with respect to major depressive disorder (adjusted HR from 1.82 to 2.07) and bipolar disorder (adjusted HR from 2.15 to 3.24). There is a greater likelihood of MD manifesting in patients with a history of sleep apnea. Health professionals are thus advised to carefully monitor the psychological impacts of sleep apnea.
Relation:	Sleep and Breathing, v.21, n.2, pp.243-253
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles

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